Acute Effect of Three Aerobic Exercise Intensities on Glomerular Filtration Rate in Healthy Older Adults.

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Diseases (Basel, Switzerland) Pub Date : 2024-10-11 DOI:10.3390/diseases12100249

Marina Trejo-Trejo, Luis M Gómez-Miranda, Arnulfo Ramos-Jiménez

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Abstract

No consensus exists on whether acute aerobic exercise alters the glomerular filtration rate in older adults.

Objective: To assess the immediate effects of three aerobic exercise intensities on the estimated glomerular filtration rate (eGFR) in healthy, sedentary older adults.

Methods: Eighteen healthy, sedentary older adults (ten men and eight women) voluntarily participated in this study. The participants underwent three standardized aerobic exercise tests (100%, 80%, and 60% of the maximal heart rate) on a bicycle ergometer. Blood samples were collected to determine cholesterol, triacylglycerols, glucose, serum creatinine (Cr), Cystatin C (CysC) concentrations, and eGFR.

Results: eGFR and serum concentrations of Cr and CysC were not modified at any exercise intensity. There was a negative correlation between blood total cholesterol vs. eGFR (R = -0.512, R = -0.582, R = -0.531; p < 0.05) at rest, 60%, and 100% of the maximal heart rate, respectively. In addition, a negative correlation existed for age vs. eGFR at 60% of the maximal heart rate (R = -0.516; p < 0.05).

Conclusions: Short-duration aerobic exercise of low, moderate, and vigorous intensity did not significantly affect eGFR and is considered safe for kidney function in healthy, sedentary older adults. However, regular monitoring of kidney function in older people engaged in moderate- and high-intensity exercise is advised.

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三种有氧运动强度对健康老年人肾小球滤过率的急性影响

关于急性有氧运动是否会改变老年人的肾小球滤过率，目前尚无共识：评估三种有氧运动强度对健康、久坐不动的老年人估计肾小球滤过率（eGFR）的直接影响：18名健康、久坐不动的老年人（10名男性和8名女性）自愿参加了这项研究。参与者在自行车测力计上进行了三次标准化有氧运动测试（最大心率的 100%、80% 和 60%）。采集血样以测定胆固醇、三酰甘油、葡萄糖、血清肌酐（Cr）、胱抑素 C（CysC）浓度和 eGFR。在静息、60% 和 100% 最大心率时，血液总胆固醇与 eGFR 之间分别存在负相关（R = -0.512、R = -0.582、R = -0.531；p < 0.05）。此外，在最大心率为 60% 时，年龄与 eGFR 呈负相关（R = -0.516；p < 0.05）：结论：低强度、中等强度和剧烈强度的短时间有氧运动对肾小球滤过率没有明显影响，对健康、久坐不动的老年人的肾功能是安全的。然而，建议定期监测从事中、高强度运动的老年人的肾功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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