Diagnostic and prognostic role of NLR in testicular cancer.

Q3 Medicine Exploration of targeted anti-tumor therapy Pub Date : 2024-01-01 Epub Date: 2024-09-19 DOI:10.37349/etat.2024.00270

Shirin Sarejloo, Saghar Babadi, Shokoufeh Khanzadeh, Amirhossein Salimi, Alec Clark, Dinyar Khazaeli, Monireh Khanzadeh, Arshin Ghaedi, Brandon Lucke-Wold

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Abstract

Background: To summarize the results of available studies for investigating the role of neutrophil to lymphocyte ratio (NLR) in testicular cancer (tCa).

Methods: The search was conducted on PubMed, Scopus, and Web of Science up to November 21, 2021. Finally, a total of 31 studies were included in this review.

Results: NLR was higher in tCa patients compared to healthy controls and benign testis pathologies, and decreased significantly after orchiectomy. An elevated NLR predicts poor prognosis, advanced stage, presence of nodal or distant metastases, contralateral tumor development, lower time-to-cancer specific death, worse OS, and poorer response to chemotherapy. However, NLR could not differentiate between seminomas and non-seminomatous tCa.

Discussion: NLR has a significant diagnostic and prognostic value in tCa.

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睾丸癌 NLR 的诊断和预后作用。

背景：总结中性粒细胞与淋巴细胞比率（NLR）在睾丸癌（tCa）中作用的现有研究结果：总结现有研究结果，探讨中性粒细胞与淋巴细胞比值（NLR）在睾丸癌（tCa）中的作用：截至 2021 年 11 月 21 日，在 PubMed、Scopus 和 Web of Science 上进行了检索。结果：睾丸癌患者的 NLR 较高：结果：与健康对照组和良性睾丸病变相比，睾丸癌患者的NLR较高，睾丸切除术后NLR显著下降。NLR升高预示着预后不良、晚期、出现结节或远处转移、对侧肿瘤发生、较低的癌症特异性死亡时间、较差的OS和较差的化疗反应。但是，NLR不能区分精原细胞瘤和非精原细胞瘤tCa：讨论：NLR对tCa具有重要的诊断和预后价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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