Fibromyalgia with elevated rheumatoid factor is associated with poor therapeutic response but not with progression to rheumatoid arthritis. Prospective cohort study.

Reumatologia clinica Pub Date : 2024-11-01 Epub Date: 2024-10-24 DOI:10.1016/j.reumae.2024.10.001

Freddy Liñán Ponce, Juan Leiva Goicochea, David Sevilla Rodríguez, Elmer Hidalgo Bravo, Ginna Obregón Atanacio, Inés Loyola Macalapú, Paola Jáuregui Rojas, Jackeline Yampufe Canani

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Abstract

Objetive: Evaluate response to treatment and progression to rheumatoid arthritis (RA) in patients with fibromyalgia (FM) associated with elevated rheumatoid factor (RF).

Material and methods: Prospective cohort study. The sample consisted of 124 patients with FM: 62 with high RF (>20 U/mL) and 62 with negative RF (0-20 U/mL). All patients were evaluated using FM treatment improvement score (FIQR) and progression to RA according to EULAR/ACR 2010 criteria at 6 and 12 months. Pearson's χ² test for homogeneity was used to relate variables of improvement to FM treatment and progression to RA.

Results: The response to treatment was lower in the high RF group (24 and 20 patients improved at 6 and 12 months, respectively, compared to 45 and 38 patients in the negative RF group), with a significant difference. Progression to rheumatoid arthritis was similar in both groups (5 in the high RF group and 4 in the negative RF group), with a non-significant relationship.

Conclusions: FM with elevated RF is associated with a poor therapeutic response but not with progression to RA.

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类风湿因子升高的纤维肌痛与治疗反应不佳有关，但与类风湿关节炎的进展无关。前瞻性队列研究。

目的：评估伴有类风湿因子（RF）升高的纤维肌痛（FM）患者对治疗的反应和类风湿关节炎（RA）的进展情况：评估伴有类风湿因子（RF）升高的纤维肌痛（FM）患者对治疗的反应以及向类风湿关节炎（RA）发展的情况：前瞻性队列研究。样本包括 124 名纤维肌痛患者：62 名 RF 高（>20 U/mL），62 名 RF 阴性（0-20 U/mL）。根据 EULAR/ACR 2010 标准，使用 FM 治疗改善评分（FIQR）对所有患者进行评估，并在 6 个月和 12 个月后评估其是否进展为 RA。用皮尔逊χ2检验同质性，将FM治疗改善和RA进展变量联系起来：高射频组的治疗反应较低（6个月和12个月时分别有24名和20名患者病情好转，而阴性射频组分别有45名和38名患者病情好转），差异显著。两组患者发展为类风湿性关节炎的情况相似（高RF组5例，阴性RF组4例），但无显著关系：RF升高的调频与治疗反应差有关，但与类风湿关节炎的进展无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Reumatologia clinica

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