Analysis of Alzheimer's Disease-Related Mortality Rates Among the Elderly Populations Across the United States: An Analysis of Demographic and Regional Disparities from 1999 to 2020.

Abdul Hadi Khan, Eman Ijaz, Bushra Ubaid, Ilias Eddaki, Maliha Edhi, Muhammad Nauman Shah, George Perry
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Abstract

Introduction: Alzheimer's Disease (AD) is the leading cause of dementia and a significant public health concern, characterized by high incidence, mortality, and economic burden. This study analyzes the mortality patterns and demographic disparities in Alzheimer's disease-related deaths among the elderly population in the United States from 1999 through 2020.

Methods: Alzheimer's disease mortality data for individuals 65 and older were obtained from the CDC WONDER database, utilizing ICD-10 codes G30.0, G30.1, G30.8, and G30.9 for identification. Demographic and regional variables included age, gender, race/ethnicity, place of death, urban- rural status, and geographic region. Crude death rates (CR) and age-adjusted mortality rates (AAMR) per 100,000 individuals were calculated. Joinpoint Regression Program 5.0.2 was used to analyze trends, calculating Annual Percentage Changes (APCs) and Average Annual Percentage Changes (AAPCs).

Results: From 1999 to 2020, 1,852,432 deaths were attributed to AD among individuals aged 65 and older. The AAMR increased from 128.8 in 1999 to 254.3 in 2020, with an AAPC of 2.99% (95% CI = 2.61-3.48). The age-adjusted mortality rate (AAMR) was higher in females (218.5) than in males (163.5). Among racial and ethnic groups, non-Hispanic whites had the highest AAMR, followed by Non-Hispanic Blacks and Hispanics. Regionally, the West reported the highest AAMR, while the Northeast recorded the lowest. Most deaths occurred in nursing homes (57.3%), with a significant portion also occurring at decedents' homes (22.4%).

Conclusion: AD mortality rates in the U.S. have risen significantly, with notable disparities across age, gender, race, and geographic regions. These findings highlight the need for targeted interventions and research to address the growing burden of AD, particularly among the most affected demographic groups.

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全美老年人口与阿尔茨海默病相关的死亡率分析:1999 至 2020 年人口和地区差异分析》。
引言阿尔茨海默病(AD)是导致痴呆症的主要原因,也是一个重大的公共卫生问题,具有发病率高、死亡率高和经济负担重的特点。本研究分析了从 1999 年到 2020 年美国老年人口中阿尔茨海默病相关死亡的死亡率模式和人口差异:从疾病预防控制中心 WONDER 数据库中获取了 65 岁及以上人群的阿尔茨海默病死亡率数据,使用 ICD-10 代码 G30.0、G30.1、G30.8 和 G30.9 进行识别。人口统计学和地区变量包括年龄、性别、种族/民族、死亡地点、城乡状况和地理区域。计算了每 10 万人的粗死亡率(CR)和年龄调整死亡率(AAMR)。使用 Joinpoint Regression Program 5.0.2 分析趋势,计算年度百分比变化 (APC) 和平均年度百分比变化 (AAPC):结果:从 1999 年到 2020 年,65 岁及以上人群中有 1,852,432 人死于注意力缺失症。AAMR从1999年的128.8增加到2020年的254.3,AAPC为2.99%(95% CI = 2.61-3.48)。女性的年龄调整死亡率(218.5)高于男性(163.5)。在种族和族裔群体中,非西班牙裔白人的年龄调整死亡率最高,其次是非西班牙裔黑人和西班牙裔。从地区来看,西部地区的 AAMR 最高,而东北部地区最低。大多数死亡发生在养老院(57.3%),也有相当一部分发生在死者家中(22.4%):结论:美国的注意力缺失症死亡率大幅上升,不同年龄、性别、种族和地理区域之间存在明显差异。这些发现突出表明,有必要开展有针对性的干预措施和研究,以解决注意力缺失症带来的日益沉重的负担,尤其是在受影响最严重的人口群体中。
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