Retinoic acid receptor responder 2 and lipid metabolic reprogramming: A new insight into brain metastasis

Cancer Innovation Pub Date : 2024-10-24 DOI:10.1002/cai2.148
Lulu Wang, Yan Gao
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Abstract

The brain is a common metastatic site for carcinoma, and metabolic reprogramming is crucial for organ-tropic metastatic formation. Li et al. found RARRES2 deficiency affected lipid metabolic reprogramming through PTEN-mTOR-SREBP1 pathway and promoted BCBrM. Other studies revealed that lipid metabolic reprogramming is part of metabolic adaptation to central nervous system. Overall, there is an intricate connection between lipid metabolism and brain metastases, and disrupting this connection may be a potential therapeutic target for BCBrM treatment.

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视黄酸受体应答器 2 与脂质代谢重编程:脑转移的新视角
脑部是癌症的常见转移部位,而代谢重编程对器官转移的形成至关重要。Li等人发现,RARRES2缺乏会通过PTEN-mTOR-SREBP1途径影响脂质代谢重编程,并促进BCBrM。其他研究表明,脂质代谢重编程是中枢神经系统代谢适应的一部分。总之,脂质代谢与脑转移之间存在着错综复杂的联系,破坏这种联系可能是治疗脑转移瘤的潜在治疗靶点。
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