{"title":"Lignin-derived Brønsted acidic catalyst for the green synthesis of biologically relevant indole derivatives","authors":"Balasubramaniyam Manikandan, Balasubramanian Indrajit Karikalan, Padmaja Gopal, Vaishanya Moorthy, Supriyo Chakraborty, Subramaniapillai Selva Ganesan","doi":"10.1007/s12039-024-02315-0","DOIUrl":null,"url":null,"abstract":"<div><p>Readily available, naturally derived lignin was transformed into a Brønsted acidic organocatalyst. The obtained catalyst was utilized in the environmentally benign synthesis of biologically relevant indole derivatives such as vibrindole, turbomycin, etc. The scope of the developed methodology was further extended for the synthesis of aniline-tethered indoles, 4H-chromene, and indolin-2-one derivatives. Further, vicinal difunctionalization was successfully carried out with the aid of the developed organocatalyst. Imperatively, all the aforementioned reactions were carried out in the aqueous medium. The reusability of the heterogeneous catalyst was also proved by carrying out the reaction with the recovered catalyst.</p><h3>Graphical abstract</h3><p>Lignin-based naturally derived Brønsted acidic organocatalyst was utilized in the environmentally benign synthesis of biologically relevant indole derivatives, 4<i>H</i>-chromene, and indolin-2-one derivatives. All the aforementioned transformations were carried out in an environmentally benign aqueous medium.\n</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Chemical Sciences","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s12039-024-02315-0","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Readily available, naturally derived lignin was transformed into a Brønsted acidic organocatalyst. The obtained catalyst was utilized in the environmentally benign synthesis of biologically relevant indole derivatives such as vibrindole, turbomycin, etc. The scope of the developed methodology was further extended for the synthesis of aniline-tethered indoles, 4H-chromene, and indolin-2-one derivatives. Further, vicinal difunctionalization was successfully carried out with the aid of the developed organocatalyst. Imperatively, all the aforementioned reactions were carried out in the aqueous medium. The reusability of the heterogeneous catalyst was also proved by carrying out the reaction with the recovered catalyst.
Graphical abstract
Lignin-based naturally derived Brønsted acidic organocatalyst was utilized in the environmentally benign synthesis of biologically relevant indole derivatives, 4H-chromene, and indolin-2-one derivatives. All the aforementioned transformations were carried out in an environmentally benign aqueous medium.
期刊介绍:
Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.