Innate memory against viruses

IF 27.7 1区医学 Q1 IMMUNOLOGY Nature Immunology Pub Date : 2024-10-28 DOI:10.1038/s41590-024-02009-2

Paula Jauregui

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抵御病毒的先天记忆

先天性免疫记忆对异源病原体提供抗原依赖性交叉保护。在《免疫》（Immunity）杂志上，Lercher 等人确定了气道驻留免疫细胞的先天性免疫记忆对第二次异源病毒感染的疾病结果的影响。作者使用小鼠适应的 SARS-CoV-2 株作为 SARS-CoV-2 恢复的小鼠感染模型。他们通过单核转座酶可访问染色质测序（snATAC-seq）/RNA测序（snRNA-seq）联合检测气道驻留细胞的表观遗传学和转录组学变化，发现肺泡巨噬细胞在感染 SARS-CoV-2 后出现了表观遗传学印记。感染 SARS-CoV-2 后的人类单核细胞也保留了表观遗传程序。作者使用不同模式识别受体激动剂刺激小鼠原发性气道驻留巨噬细胞的体外培养，结果表明，与先前 SARS-CoV-2 感染相关的表观遗传印记会产生抗病毒先天免疫记忆。作者用甲型流感病毒挑战从 SARS-CoV-2 中恢复的小鼠，观察到了较轻的病理变化。将从康复小鼠体内分离出的气道驻留巨噬细胞转移到T细胞耗竭的天真受体小鼠体内，也得到了类似的结果。过去的 SARS-CoV-2 感染可改善与继发甲型流感病毒感染相关的病理变化：免疫 https://doi.org/10.1016/j.immuni.2024.08.018 (2024)

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.