IL-1α in aging tumors

IF 27.7 1区医学 Q1 IMMUNOLOGY Nature Immunology Pub Date : 2024-10-28 DOI:10.1038/s41590-024-02013-6

Stephanie Houston

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衰老肿瘤中的 IL-1α

衰老是癌症的一个危险因素，但衰老影响肿瘤控制的机制仍不清楚。Park 等人在《科学》（Science）杂志上发现，衰老与紧急骨髓造血功能增强有关，导致肿瘤中产生 IL-1α 的髓系祖细胞（MP）样细胞聚集，从而推动肿瘤生长。作者利用非小细胞肺癌（NSCLC）模型发现，老年小鼠的肿瘤负荷比年轻小鼠大，肿瘤中单核细胞衍生的巨噬细胞和肺MPs的积累增加。当老年小鼠接受年轻小鼠的骨髓移植时，肿瘤负荷会减轻；反之，当年轻小鼠接受老年小鼠的骨髓移植时，肿瘤负荷会加重。IL-1α在年长小鼠肿瘤中的MPs中上调，阻断IL-1α可延缓肿瘤进展，减少肿瘤中的MPs，并减少骨髓中造血干细胞（HSC）向粒细胞-单核细胞祖系的承诺。健康老年小鼠的造血干细胞下调了Dnmt3a的表达，用DNMT3A抑制剂处理单核细胞会导致IL-1α的产生增加。用PD-1阻断抗体和IL-1R1拮抗剂anakinra治疗老年肿瘤小鼠时，肿瘤细胞的清除率比单独使用PD-1阻断剂时有所提高，NK细胞的反应也有所增强。作者建议，IL-1R抑制剂可用于老年患者NSCLC的治疗：科学 https://doi.org/10.1126/science.adn0327 (2024)

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.