Understanding the synergistic sensitization of natural products and antibiotics: An effective strategy to combat MRSA

IF 6 2区 医学 Q1 CHEMISTRY, MEDICINAL European Journal of Medicinal Chemistry Pub Date : 2024-10-28 DOI:10.1016/j.ejmech.2024.117012
Sisi Chen, Ziling Zhi, Wing-Leung Wong, Wenchang Yuan, Ning Sun
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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common multi-resistant organisms found in hospital-acquired infections and is associated with high morbidity and mortality. The development of new drugs and promising therapeutic strategies against MRSA is thus an urgent request. In recent years, some natural products have been demonstrated to show great potential in improving the efficacy of antibiotics to treat various drug-resistant bacteria, particularly MRSA. In this context, we aimed to analyze systematically from the prior arts that investigated the synergy between natural products and antibiotics against MRSA. These findings not only give us a better understanding on the mechanism of actions but also shed light on the bioactive molecular scaffolds identified from diverse natural products. In the present study, we concentratedly reviewed the studies that utilized natural products to enhance the potency of conventional antibiotics against MRSA in the last decade. The timely information reported herein may give meaningful insights into the molecular design of novel and potent antibacterial agents and/or effective therapeutics to combat MRSA for practical applications.

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了解天然产品和抗生素的协同增敏作用:抗击 MRSA 的有效策略
耐甲氧西林金黄色葡萄球菌(MRSA)是医院感染中最常见的多重耐药菌之一,与高发病率和高死亡率有关。因此,开发针对 MRSA 的新药和有前景的治疗策略成为当务之急。近年来,一些天然产物被证明在提高抗生素治疗各种耐药菌(尤其是 MRSA)的疗效方面具有巨大潜力。在此背景下,我们旨在系统分析研究天然产品与抗生素对 MRSA 协同作用的现有技术。这些发现不仅能让我们更好地了解抗生素的作用机制,还能揭示从多种天然产物中发现的生物活性分子支架。在本研究中,我们集中回顾了近十年来利用天然产物增强常规抗生素对 MRSA 的药效的研究。本文所报告的及时信息可能会为新型强效抗菌剂和/或有效治疗药物的分子设计提供有意义的见解,从而在实际应用中对抗 MRSA。
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来源期刊
CiteScore
11.70
自引率
9.00%
发文量
863
审稿时长
29 days
期刊介绍: The European Journal of Medicinal Chemistry is a global journal that publishes studies on all aspects of medicinal chemistry. It provides a medium for publication of original papers and also welcomes critical review papers. A typical paper would report on the organic synthesis, characterization and pharmacological evaluation of compounds. Other topics of interest are drug design, QSAR, molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis and drug targeting. The journal expects manuscripts to present the rational for a study, provide insight into the design of compounds or understanding of mechanism, or clarify the targets.
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