Adeno-associated viral vectors deliver gene vaccines

IF 6 2区 医学 Q1 CHEMISTRY, MEDICINAL European Journal of Medicinal Chemistry Pub Date : 2024-10-28 DOI:10.1016/j.ejmech.2024.117010
Lai Wei, Peng Yu, Haomeng Wang, Jiang Liu
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Abstract

Adeno-associated viruses (AAVs) are leading platforms for in vivo delivery of gene therapies, with six licensed AAV-based therapeutics attributed to their non-pathogenic nature, low immunogenicity, and high efficiency. In the realm of gene-based vaccines, one of the most vital therapeutic areas, AAVs are also emerging as promising delivery tools. We scrutinized AAVs, focusing on their virological properties, as well as bioengineering and chemical modifications to demonstrate their significant potential in gene vaccine delivery, and detailing the preparation of AAV particles. Additionally, we summarized the use of AAV vectors in vaccines for both infectious and non-infectious diseases, such as influenza, COVID-19, Alzheimer's disease, and cancer. Furthermore, this review, along with the latest clinical trial updates, provides a comprehensive overview of studies on the potential of using AAV vectors for gene vaccine delivery. It aims to deepen our understanding of the challenges and limitations in nucleic acid delivery and pave the way for future clinical success.

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腺相关病毒载体提供基因疫苗
腺相关病毒(AAV)是体内输送基因疗法的主要平台,由于其非致病性、低免疫原性和高效率,目前已有六种获得许可的基于 AAV 的疗法。在最重要的治疗领域之一--基因疫苗领域,AAV 也正在成为前景广阔的递送工具。我们仔细研究了 AAV,重点关注其病毒学特性、生物工程和化学修饰,以证明其在基因疫苗递送方面的巨大潜力,并详细介绍了 AAV 粒子的制备方法。此外,我们还总结了 AAV 载体在流感、COVID-19、老年痴呆症和癌症等传染性和非传染性疾病疫苗中的应用。此外,这篇综述连同最新的临床试验更新,全面概述了使用 AAV 载体进行基因疫苗递送的潜力研究。它旨在加深我们对核酸递送的挑战和局限性的理解,为未来的临床成功铺平道路。
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来源期刊
CiteScore
11.70
自引率
9.00%
发文量
863
审稿时长
29 days
期刊介绍: The European Journal of Medicinal Chemistry is a global journal that publishes studies on all aspects of medicinal chemistry. It provides a medium for publication of original papers and also welcomes critical review papers. A typical paper would report on the organic synthesis, characterization and pharmacological evaluation of compounds. Other topics of interest are drug design, QSAR, molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis and drug targeting. The journal expects manuscripts to present the rational for a study, provide insight into the design of compounds or understanding of mechanism, or clarify the targets.
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