{"title":"[m<sup>6</sup>A RNA methylation is a potential biological target for neuropathic pain].","authors":"Yu-Ting Zhang, Li-Cai Zhang","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>N6-methyladenosine (m<sup>6</sup>A) is the most common type of RNA modification in eukaryotes, which affects intracellular RNA metabolism and controls gene expression of related pathophysiological processes through dynamic reversible regulation of methyltransferases, demethylases and m<sup>6</sup>A-binding proteins. In recent years, the involvement of m<sup>6</sup>A methylation in the study of neuropathic pain has become a hot topic, some new understandings have been emerging, and m<sup>6</sup>A methylation has become a potential biological target for the treatment of neuropathic pain. Therefore, this article reviews the role and regulation of m<sup>6</sup>A methylation in neuropathic pain, in order to provide new enlightenment for the drug development and treatment of neuropathic pain.</p>","PeriodicalId":7134,"journal":{"name":"生理学报","volume":"76 5","pages":"809-817"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"生理学报","FirstCategoryId":"1087","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
N6-methyladenosine (m6A) is the most common type of RNA modification in eukaryotes, which affects intracellular RNA metabolism and controls gene expression of related pathophysiological processes through dynamic reversible regulation of methyltransferases, demethylases and m6A-binding proteins. In recent years, the involvement of m6A methylation in the study of neuropathic pain has become a hot topic, some new understandings have been emerging, and m6A methylation has become a potential biological target for the treatment of neuropathic pain. Therefore, this article reviews the role and regulation of m6A methylation in neuropathic pain, in order to provide new enlightenment for the drug development and treatment of neuropathic pain.
期刊介绍：
Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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