Ke Han, Zi-Xia Ding, Xiao-Yu He, Tian-Yu Wu, Yu-Hang Meng, Bang Du, Xiao-Nan Zhang
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引用次数: 0
Abstract
The etiology of rheumatoid arthritis (RA), a chronic inflammatory systemic disease, remains unclear. It is characterized by symmetrical and invasive joint inflammation, primarily affecting distal small joints such as those in the hands and feet. This inflammation can lead to joint deformity and loss of function, and often accompanied by involvement of extra-articular organs like the lungs and heart. Currently, anti-rheumatic drugs only provide symptom improvement but have toxic side effects that require optimization. Therefore, it is crucial to thoroughly analyze the mechanisms underlying RA development for the identification of new drug targets. Programmed cell death (PCD) has been extensively studied in recent years and proved to be one of the key pathogenic factors in RA. Dysregulation of PCD is particularly evident in synoviocytes, immune cells, and osteocytes. This review summarizes various forms of PCD including apoptosis, NETosis, autophagy, pyroptosis, necroptosis, ferroptosis, cuproptosis, as well as their regulatory roles in fibroblast synoviocytes, immune cells and osteocytes. These findings hold significant theoretical implications for optimizing clinical treatment options for RA and developing new target drugs.
类风湿性关节炎(RA)是一种慢性全身性炎症性疾病,其病因至今仍不清楚。其特点是对称性和侵袭性关节炎症,主要影响远端小关节,如手部和足部关节。这种炎症可导致关节畸形和功能丧失,通常还伴有肺和心脏等关节外器官的受累。目前,抗风湿药物只能改善症状,但其毒副作用需要优化。因此,透彻分析 RA 的发病机制以确定新的药物靶点至关重要。近年来,人们对程序性细胞死亡(PCD)进行了广泛研究,并证明它是RA的关键致病因素之一。PCD失调在滑膜细胞、免疫细胞和骨细胞中尤为明显。本综述总结了PCD的各种形式,包括凋亡、NETosis、自噬、热凋亡、坏死凋亡、铁凋亡、杯状凋亡,以及它们在成纤维滑膜细胞、免疫细胞和骨细胞中的调控作用。这些发现对优化RA的临床治疗方案和开发新的靶向药物具有重要的理论意义。
期刊介绍:
Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.