Latent change-on-change between amyloid accumulation and cognitive decline.

IF 13 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-10-29 DOI:10.1002/alz.14326

Hannah M Klinger, Brian C Healy, Bernard J Hanseeuw, Rich N Jones, Rory Boyle, Diana L Townsend, Michael J Properzi, Gillian T Coughlan, Mabel Seto, Colin Birkenbihl, Michelle E Farrell, Kathryn V Papp, Jasmeer P Chhatwal, Hyun-Sik Yang, Aaron P Schultz, Rebecca E Amariglio, Heidi I L Jacobs, Julie C Price, Keith A Johnson, Dorene M Rentz, Reisa A Sperling, Rachel F Buckley

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Abstract

Introduction: While the influence of cross-sectional β-amyloid (Aβ) on longitudinal changes in cognition is well established, longitudinal change-on-change between Aβ and cognition is less explored.

Methods: A series of bivariate latent change score models (LCSM) examined the relationship between changes in ¹¹C-Pittsburgh Compound-B (PiB) positron emission tomography (PET) and the Preclinical Alzheimer's Cognitive Composite-5 (PACC-5) while adjusting for covariates, including cross-sectional medial temporal lobe (MTL) tau-PET burden. We selected 352 clinically normal older participants with up to 9 years of PiB-PET and PACC-5 data from the Harvard Aging Brain Study (HABS).

Results: Aβ accumulation was associated with subsequent cognitive decline beyond the effects of cross-sectional Aβ burden. Within this model including covariates such as age, sex, and apolipoprotein ε4 (APOEε4) status, we found no evidence supporting previously published associations between cross-sectional tau-PET and cognitive intercept/slope.

Discussion: Short-term Aβ changes are significantly associated with cognitive decline in clinically normal older adults and may eclipse the effect of cross-sectional Aβ and MTL tau.

Highlights: Aβ accumulation is associated with subsequent cognitive decline. High Aβ burden is not the sole metric signaling impending cognitive decline. Contrary to prior work, MTL tau-PET and cognition were not associated in our models. Models of bivariate latent Aβ and cognitive change may eclipse the effects of MTL tau.

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淀粉样蛋白积累与认知能力下降之间的潜伏变化。

简介虽然β-淀粉样蛋白（Aβ）的横断面对认知纵向变化的影响已得到公认，但Aβ和认知之间的纵向变化对变化的影响却鲜有探讨：一系列双变量潜在变化评分模型（LCSM）研究了11C-匹兹堡化合物-B（PiB）正电子发射断层扫描（PET）的变化与临床前阿尔茨海默氏症认知综合-5（PACC-5）之间的关系，同时调整了协变量，包括横断面内侧颞叶（MTL）tau-PET负荷。我们从哈佛大学老年脑研究（HABS）中挑选了352名临床正常的老年参与者，他们拥有长达9年的PiB-PET和PACC-5数据：结果：除了横断面 Aβ 负荷的影响外，Aβ 累积还与随后的认知能力下降有关。在这个包括年龄、性别和载脂蛋白ε4（APOEε4）状态等协变量的模型中，我们没有发现证据支持之前发表的横断面tau-PET与认知截距/斜率之间的关联：讨论：Aβ的短期变化与临床正常老年人的认知能力下降密切相关，可能会削弱横断面Aβ和MTL tau的影响：亮点：Aβ累积与随后的认知能力下降有关。高Aβ负荷并不是预示认知能力即将下降的唯一指标。与之前的研究相反，在我们的模型中，MTL tau-PET和认知能力并不相关。双变量潜Aβ和认知变化模型可能会掩盖MTL tau的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.