Comparison of the Efficacy of Transcatheter Arterial Chemoembolization Combined with Radiofrequency Ablation Versus Monotherapy in Patients with Liver Cancer.

IF 0.9 4区医学 Q3 SURGERY Annali italiani di chirurgia Pub Date : 2024-01-01 DOI:10.62713/aic.3341

Shanfeng Li, Feng Zhao, Meng Sun, Haisong Wang, Jiangtao Bai, Long Zhou

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Abstract

Aim: This study assesses the effectiveness of combining transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) in treating hepatocellular carcinoma (HCC).

Methods: Retrospective analysis of 125 HCC patients treated from 2020 to 2021, divided into two groups: monotherapy using TACE (n = 63), and a combined approach of RFA and TACE (n = 62). Comparison factors included clinical efficacy, liver function, tumor markers, complications, quality of life, and prognosis.

Results: The combined treatment group showed higher effectiveness (p < 0.05), improved liver function and tumor marker levels 4 weeks post-treatment (p < 0.05), significantly fewer complications (p < 0.05), and enhanced quality of life at the year-long follow-up (p < 0.05). The prognosis was better in the combination group, demonstrated by fewer recurrences and higher 1-year survival rates (p < 0.05).

Conclusions: The dual approach of TACE and RFA shows improved results for HCC patients, including improved liver function, reduced tumor markers, fewer complications, and superior quality of life and prognosis. Consequently, combined treatment approach is endorsed for clinical practice.

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肝癌患者经导管动脉化疗栓塞术联合射频消融与单一疗法的疗效比较

目的：本研究评估了经导管动脉化疗栓塞术（TACE）和射频消融术（RFA）联合治疗肝细胞癌（HCC）的效果：回顾性分析2020年至2021年接受治疗的125例HCC患者，分为两组：使用TACE的单一疗法（n = 63）和RFA与TACE的联合疗法（n = 62）。比较因素包括临床疗效、肝功能、肿瘤标志物、并发症、生活质量和预后：结果：联合治疗组疗效更高（P < 0.05），治疗后 4 周肝功能和肿瘤标志物水平有所改善（P < 0.05），并发症明显减少（P < 0.05），随访一年后生活质量有所提高（P < 0.05）。联合治疗组的预后更好，复发率更低，1年生存率更高（P < 0.05）：结论：TACE 和 RFA 双管齐下可改善 HCC 患者的治疗效果，包括改善肝功能、降低肿瘤标志物、减少并发症、提高生活质量和预后。因此，临床实践认可联合治疗方法。

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来源期刊

Annali italiani di chirurgia 医学-外科

CiteScore

0.90

自引率

12.50%

发文量

116

审稿时长

>12 weeks

期刊介绍： Annali Italiani di Chirurgia is a bimonthly journal and covers all aspects of surgery:elective, emergency and experimental surgery, as well as problems involving technology, teaching, organization and forensic medicine. The articles are published in Italian or English, though English is preferred because it facilitates the international diffusion of the journal (v.Guidelines for Authors and Norme per gli Autori). The articles published are divided into three main sections:editorials, original articles, and case reports and innovations.