Clinical characteristics and factors associated with mucus plugs under bronchoscopy in children hospitalized for acute asthma attack.

IF 2.1 3区医学 Q2 PEDIATRICS Frontiers in Pediatrics Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI:10.3389/fped.2024.1382680

Peng Han, Anxia Jiao, Ju Yin, Huimin Zou, Yuliang Liu, Zheng Li, Quan Wang, Jie Wu, Kunling Shen

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Abstract

Objective: To describe clinical characteristics of hospitalized children with acute asthma attacks complicated with mucus plugs and to investigate the factors associated with mucus plugs in asthma children.

Methods: This retrospective study analyzed hospitalized children and adolescents with acute asthma attacks from January 2016 to December 2021. The demographic information and characteristics were collected. Subjects were categorized into the mucus plug group and the control group based on the bronchoalveolar lavage results. The Logistic regression analyses were utilized to assess the relative factors associated with mucus plugs. All data were analyzed using SPSS 22.0.

Results: This study included 242 individuals. Out of the 151 subjects who underwent bronchoscopy, 62.9% were classified in the mucus plug group and 37.1% in the control group. The subjects with dyspnea had a higher proportion in the mucus plug group (52.6% vs. 26.8%). The serum total IgE level of the mucus plug group was lower than the control group. The proportion of subjects who were diagnosed with asthma for the first time during hospitalization (87.4% vs. 76.8%) and combined with respiratory infection (91.6% vs. 82.1%) in the mucus plug group might be higher than that in the control group. More subjects in the mucus plug group were administered systemic glucocorticoid, magnesium sulfate, aminophylline, and mucolytic drugs after hospitalization. In multivariable analysis, diagnosed with asthma for the first time during hospitalization (OR = 4.404; 1.101-17.614), dyspnea (OR = 4.039; 1.306-12.496), and cesarean (OR = 0.274; 0.092-0.812) might be associated with mucus plug in children hospitalized for an acute asthma attack.

Suggests: While our retrospective study suggests that some clinical features of children hospitalized with asthma who have mucus plugs differ from those without, further studies are required.

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因哮喘急性发作住院治疗的儿童支气管镜下粘液栓的临床特征及相关因素。

目的描述急性哮喘发作并发粘液栓的住院患儿的临床特征，并研究与哮喘患儿粘液栓相关的因素：这项回顾性研究分析了 2016 年 1 月至 2021 年 12 月期间哮喘急性发作的住院儿童和青少年。研究收集了人口统计学信息和特征。根据支气管肺泡灌洗结果将受试者分为粘液栓塞组和对照组。利用逻辑回归分析评估与粘液栓相关的相对因素。所有数据均使用 SPSS 22.0 进行分析：本研究共纳入 242 人。在接受支气管镜检查的 151 名受试者中，62.9% 属于粘液栓组，37.1% 属于对照组。有呼吸困难的受试者在粘液栓组中所占比例较高（52.6% 对 26.8%）。粘液栓组的血清总 IgE 水平低于对照组。粘液栓组在住院期间首次诊断为哮喘（87.4% 对 76.8%）和合并呼吸道感染（91.6% 对 82.1%）的受试者比例可能高于对照组。粘液栓组有更多的患者在住院后全身使用糖皮质激素、硫酸镁、氨茶碱和粘液溶解药物。在多变量分析中，住院期间首次诊断为哮喘（OR = 4.404; 1.101-17.614）、呼吸困难（OR = 4.039; 1.306-12.496）和剖腹产（OR = 0.274; 0.092-0.812）可能与哮喘急性发作住院患儿的粘液栓有关：建议：虽然我们的回顾性研究表明，哮喘住院患儿的某些临床特征与无粘液栓的患儿有所不同，但仍需进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Pediatrics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

3.60

自引率

7.70%

发文量

2132

审稿时长

14 weeks

期刊介绍： Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.