Role of serum kisspeptin as a biomarker to detect miscarriage: a systematic review and meta-analysis.

IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Human Fertility Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI:10.1080/14647273.2024.2417934
Sisi Ye, Liping Zhou
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Abstract

Miscarriage is a common adverse pregnancy outcome with physical and emotional effects. Identifying predictive miscarriage biomarkers should improve early detection and management. Serum kisspeptin, known for its critical role in reproductive biology, has emerged as a potential biomarker for miscarriage. With this systematic review and meta-analysis, we aimed to assess the association between serum kisspeptin levels and the miscarriage risk. We systematically searched PubMed, Embase, and Cochrane Library databases for studies published up to February 2024, examining the association between serum kisspeptin levels and miscarriage. Eligible studies were observational designs that reported kisspeptin levels in women with and without miscarriage. We included 12 studies involving 2,050 participants. Pooled analysis demonstrated that low serum kisspeptin levels were significantly associated with an increased risk of miscarriage (standardized mean difference = -2.750; 95%CI: -4.357 to -1.143), with substantial heterogeneity (I2 = 98.7%). The pooled area under the curve from three studies indicated high diagnostic accuracy (AUC = 0.903; 95%CI: 0.860-0.946). Low serum kisspeptin levels are significantly associated with an increased miscarriage risk, suggesting that kisspeptin could serve as an effective biomarker for early detection. However, the significant heterogeneity among studies and the lack of standardized measurement protocols emphasize the necessity of further research before clinical implementation. SYSTEMATIC REVIEW REGISTRATION: (Registration ID: CRD42024520639).

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血清吻肽作为检测流产的生物标志物的作用:系统综述和荟萃分析。
流产是一种常见的不良妊娠结局,会对身体和情绪造成影响。确定预测流产的生物标志物可改善早期检测和管理。血清kisspeptin因其在生殖生物学中的关键作用而闻名,现已成为流产的潜在生物标志物。本系统综述和荟萃分析旨在评估血清吻肽水平与流产风险之间的关联。我们系统检索了 PubMed、Embase 和 Cochrane Library 数据库中截至 2024 年 2 月发表的研究,这些研究探讨了血清吻肽水平与流产之间的关系。符合条件的研究均为观察性设计,报告了流产和未流产妇女的吻普汀水平。我们共纳入了 12 项研究,涉及 2,050 名参与者。汇总分析表明,低血清吻肽水平与流产风险增加有显著相关性(标准化平均差 = -2.750;95%CI:-4.357 至 -1.143),但存在很大的异质性(I2 = 98.7%)。三项研究的汇总曲线下面积显示诊断准确率很高(AUC = 0.903;95%CI:0.860-0.946)。血清吻肽水平低与流产风险增加显著相关,这表明吻肽可作为早期检测的有效生物标志物。然而,不同研究之间存在明显的异质性,而且缺乏标准化的测量方案,因此在临床应用之前有必要开展进一步的研究。系统审查注册:(注册编号:CRD42024520639)。
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来源期刊
Human Fertility
Human Fertility OBSTETRICS & GYNECOLOGY-REPRODUCTIVE BIOLOGY
CiteScore
3.30
自引率
5.30%
发文量
50
期刊介绍: Human Fertility is a leading international, multidisciplinary journal dedicated to furthering research and promoting good practice in the areas of human fertility and infertility. Topics included span the range from molecular medicine to healthcare delivery, and contributions are welcomed from professionals and academics from the spectrum of disciplines concerned with human fertility. It is published on behalf of the British Fertility Society. The journal also provides a forum for the publication of peer-reviewed articles arising out of the activities of the Association of Biomedical Andrologists, the Association of Clinical Embryologists, the Association of Irish Clinical Embryologists, the British Andrology Society, the British Infertility Counselling Association, the Irish Fertility Society and the Royal College of Nursing Fertility Nurses Group. All submissions are welcome. Articles considered include original papers, reviews, policy statements, commentaries, debates, correspondence, and reports of sessions at meetings. The journal also publishes refereed abstracts from the meetings of the constituent organizations.
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