Efficacy, drug survival, safety and metabolic parameters of ixekizumab in patients with moderate-to-severe psoriasis in China: A two-year real-world study

IF 4.8 2区医学 Q2 IMMUNOLOGY International immunopharmacology Pub Date : 2024-10-29 DOI:10.1016/j.intimp.2024.113474

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Abstract

Long-term, real-world studies of the efficacy and metabolic parameters of ixekizumab in difficult-to-treat areas of psoriasis are lacking. A two-year retrospective study was conducted to evaluate the long-term efficacy, safety, drug survival and metabolic parameters of ixekizumab in the real world. A total of 258 patients were enrolled. At 52 weeks, PASI 75/90/100 was achieved in 92.0 %, 79.8 % and 54.6 % of patients, respectively. The efficacy was maintained at week 104 with PASI 75/90/100 of 92.6 %, 81.5 % and 48.1 %, respectively. At week 12, sPGA 0/1 was achieved in 71.0 % of scalp psoriasis, 60.0 % of palmoplantar psoriasis and 68.8 % of genital psoriasis. The probability of drug survival at 12 and 24 months was 67.1 % and 56.3 %, respectively. The most common adverse events included local injection reactions (31.8 %), allergies (11.6 %) and infections (6.1 %). No disease activation was observed in patients with latent tuberculosis or hepatitis B/C. No hyperlipidemia or hyperglycemia was observed. This study confirmed the long-term efficacy, high drug survival and favorable safety of ixekizumab in a real-world setting.

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ixekizumab在中国中重度银屑病患者中的疗效、药物存活率、安全性和代谢参数：一项为期两年的真实世界研究。

目前还缺乏对ixekizumab在银屑病难治部位的疗效和代谢参数的长期实际研究。我们开展了一项为期两年的回顾性研究，以评估ixekizumab在真实世界中的长期疗效、安全性、药物存活率和代谢参数。共有 258 名患者参与了这项研究。52周时，分别有92.0%、79.8%和54.6%的患者PASI达到75/90/100。疗效在第 104 周得以保持，PASI 75/90/100 分别为 92.6%、81.5% 和 48.1%。第 12 周时，71.0% 的头皮银屑病、60.0% 的掌跖银屑病和 68.8% 的生殖器银屑病患者的 sPGA 达到 0/1。12 个月和 24 个月的药物存活率分别为 67.1% 和 56.3%。最常见的不良反应包括局部注射反应（31.8%）、过敏（11.6%）和感染（6.1%）。在潜伏肺结核或乙型/丙型肝炎患者中未发现疾病激活现象。没有观察到高脂血症或高血糖。这项研究证实了ixekizumab在现实世界中的长期疗效、高药物存活率和良好的安全性。

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来源期刊

International immunopharmacology 医学-免疫学

CiteScore

8.40

自引率

3.60%

发文量

935

审稿时长

53 days

期刊介绍： International Immunopharmacology is the primary vehicle for the publication of original research papers pertinent to the overlapping areas of immunology, pharmacology, cytokine biology, immunotherapy, immunopathology and immunotoxicology. Review articles that encompass these subjects are also welcome. The subject material appropriate for submission includes: • Clinical studies employing immunotherapy of any type including the use of: bacterial and chemical agents; thymic hormones, interferon, lymphokines, etc., in transplantation and diseases such as cancer, immunodeficiency, chronic infection and allergic, inflammatory or autoimmune disorders. • Studies on the mechanisms of action of these agents for specific parameters of immune competence as well as the overall clinical state. • Pre-clinical animal studies and in vitro studies on mechanisms of action with immunopotentiators, immunomodulators, immunoadjuvants and other pharmacological agents active on cells participating in immune or allergic responses. • Pharmacological compounds, microbial products and toxicological agents that affect the lymphoid system, and their mechanisms of action. • Agents that activate genes or modify transcription and translation within the immune response. • Substances activated, generated, or released through immunologic or related pathways that are pharmacologically active. • Production, function and regulation of cytokines and their receptors. • Classical pharmacological studies on the effects of chemokines and bioactive factors released during immunological reactions.