{"title":"Gene of the month: C-KIT.","authors":"Niraj Kumari, Raghavendra Lingaiah","doi":"10.4103/ijc.ijc_1350_21","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>KIT is a gene coding for tyrosine kinase receptor, which was identified as the ligand of stem cell factor. Its role in disease was first identified in gastrointestinal stromal tumor. However, later, this gene was found to be implicated in many other benign and malignant tumors. C-KIT has been studied as the first biomarker for targeted therapy. Herein we review its structure, function and role in various non-neoplastic and neoplastic diseases.</p>","PeriodicalId":13505,"journal":{"name":"Indian journal of cancer","volume":" ","pages":""},"PeriodicalIF":0.9000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian journal of cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/ijc.ijc_1350_21","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract: KIT is a gene coding for tyrosine kinase receptor, which was identified as the ligand of stem cell factor. Its role in disease was first identified in gastrointestinal stromal tumor. However, later, this gene was found to be implicated in many other benign and malignant tumors. C-KIT has been studied as the first biomarker for targeted therapy. Herein we review its structure, function and role in various non-neoplastic and neoplastic diseases.
期刊介绍：
Indian Journal of Cancer (ISSN 0019-509X), the show window of the progress of ontological sciences in India, was established in 1963. Indian Journal of Cancer is the first and only periodical serving the needs of all the specialties of oncology in India.
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