Reasons for acceptance or nonparticipation in iAdhere: a trial of latent TB infection treatment.

IF 3.4 3区 医学 Q2 INFECTIOUS DISEASES International Journal of Tuberculosis and Lung Disease Pub Date : 2024-11-01 DOI:10.5588/ijtld.23.0599
K N Chapman Hedges, N Scott, R Belknap, S V Goldberg, M Engle, A Borisov, J Mangan
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Abstract

BACKGROUNDUnderstanding the motivations behind clinical trial participation can help enhance recruitment strategies and determine the generalizability of trial results. This study focuses on the reasons for participating in or declining the Tuberculosis Trials Consortium Study 33 (iAdhere), a clinical trial on the treatment of latent tuberculosis infection (LTBI).METHODSA quantitative evaluation was conducted among screened patients to ascertain their reasons for participating or not in the iAdhere trial. The study gathered data from enrolled participants and those who chose not to enroll.RESULTSAmong 1,002 enrolled individuals, 290 participants provided 749 reasons for enrolling. The most common reasons included access to shorter treatment regimens (56%), avoiding progression to TB disease (45%), and improving health (21%). Of the 670 eligible persons who chose not to enroll, 551 individuals provided 800 reasons, with the most common being a preference for standard therapy (17%), disinterest in study medication or TB therapy (both 13%), and the inconvenience of daily observed treatment (12%).CONCLUSIONThe desire for shorter treatment options and preventing active disease motivates participation in LTBI trials. The diverse reasons for declining enrolment suggest the importance of developing targeted recruitment strategies. These findings support exploring shorter treatment regimens and can guide future recruitment efforts..

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接受或不参与 iAdhere:潜伏肺结核感染治疗试验的原因。
背景了解参与临床试验的动机有助于加强招募策略并确定试验结果的可推广性。本研究主要探讨了参与或拒绝参与结核病试验联盟第 33 项研究(iAdhere)的原因,这是一项治疗潜伏结核感染(LTBI)的临床试验。结果在 1002 名参加者中,有 290 名参加者提供了 749 个参加原因。最常见的原因包括获得更短的治疗方案(56%)、避免结核病恶化(45%)和改善健康状况(21%)。在选择不参加试验的 670 名符合条件者中,551 人提供了 800 条理由,其中最常见的是倾向于标准疗法(17%)、对研究药物或结核疗法不感兴趣(均为 13%)以及不便进行每日观察治疗(12%)。拒绝参加试验的原因多种多样,这表明制定有针对性的招募策略非常重要。这些发现支持探索更短的治疗方案,并能指导未来的招募工作。
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来源期刊
CiteScore
4.90
自引率
20.00%
发文量
266
审稿时长
2 months
期刊介绍: The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.
期刊最新文献
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