Clinical potential of epigenetic and microRNA biomarkers in PTSD.

IF 1.8 4区 医学 Q3 GENETICS & HEREDITY Journal of neurogenetics Pub Date : 2024-10-29 DOI:10.1080/01677063.2024.2419098
Nathan J Wellington, Ana P Boucas, Jim Lagopoulos, Anna V Kuballa
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Abstract

Molecular studies identifying alterations associated with PTSD have predominantly focused on candidate genes or conducted genome-wide analyses, often encountering issues with replicability. This review aims to identify robust bi-directional epigenetic and microRNA (miRNA) regulators focusing on their functional impacts on post-traumatic stress disorder (PTSD) and their utility in clinical diagnosis, whilst examining knowledge gaps in the existing research. A systematic search was conducted across multiple databases, including Web of Science, Scopus, Global Health (CABI), and PubMed, augmented by grey literature, yielding 3465 potential articles. Ultimately, 92 studies met the inclusion criteria and were analysed to pinpoint significant epigenetic changes with clinically relevant potential in PTSD. The selected studies explored histone modifications, CpG sites, single nucleotide polymorphisms (SNPs), and miRNA biomarkers. Specifically, nine studies examined epigenetic markers, detailing the influence of methylation on chromatin accessibility at histone positions H3K4, H3K9, and H3K36 within a PTSD context. Seventy-three studies investigated DNA methylation, identifying 20 hypermethylated and five hypomethylated CpG islands consistently observed in PTSD participants. Nineteen studies linked 88 SNPs to PTSD, with only one SNP replicated within these studies. Furthermore, sixteen studies focused on miRNAs, with findings indicating 194 downregulated and 24 upregulated miRNAs were associated with PTSD. Although there are epigenetic mechanisms that are significantly affected by PTSD, a granular deconstruction of these mechanisms elucidates the need to incorporate more nuanced approaches to identifying the factors that contribute to PTSD. Technological advances in diagnostic tools are driving the need to integrate detailed participant characteristics, trauma type, genetic susceptibilities, and best practices for robust reporting. This comprehensive approach will be crucial for enhancing the translational potential of PTSD research for clinical application.

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创伤后应激障碍的表观遗传学和微RNA生物标记的临床潜力。
确定创伤后应激障碍相关改变的分子研究主要集中于候选基因或进行全基因组分析,经常遇到可复制性问题。本综述旨在确定稳健的双向表观遗传和微RNA(miRNA)调控因子,重点关注它们对创伤后应激障碍(PTSD)的功能影响及其在临床诊断中的作用,同时检查现有研究中的知识空白。我们在多个数据库(包括 Web of Science、Scopus、Global Health (CABI) 和 PubMed)中进行了系统性检索,并对灰色文献进行了补充,共检索到 3465 篇潜在文章。最终,有 92 项研究符合纳入标准,经分析后确定了创伤后应激障碍中具有临床相关潜力的重要表观遗传变化。所选研究探讨了组蛋白修饰、CpG 位点、单核苷酸多态性 (SNP) 和 miRNA 生物标记物。具体来说,九项研究考察了表观遗传标记,详细研究了在创伤后应激障碍的背景下,甲基化对组蛋白位置 H3K4、H3K9 和 H3K36 的染色质可及性的影响。73 项研究对 DNA 甲基化进行了调查,在创伤后应激障碍患者中发现了 20 个高甲基化和 5 个低甲基化的 CpG 岛。有 19 项研究将 88 个 SNP 与创伤后应激障碍联系起来,其中只有一个 SNP 在这些研究中得到了重复。此外,有 16 项研究关注 miRNA,结果表明有 194 个下调和 24 个上调的 miRNA 与创伤后应激障碍有关。尽管创伤后应激障碍对表观遗传机制有显著影响,但对这些机制的细化解构阐明,需要采用更细致的方法来确定导致创伤后应激障碍的因素。诊断工具的技术进步促使人们需要整合详细的参与者特征、创伤类型、遗传易感性和健全报告的最佳实践。这种综合方法对于提高创伤后应激障碍研究在临床应用中的转化潜力至关重要。
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来源期刊
Journal of neurogenetics
Journal of neurogenetics 医学-神经科学
CiteScore
4.40
自引率
0.00%
发文量
13
审稿时长
>12 weeks
期刊介绍: The Journal is appropriate for papers on behavioral, biochemical, or cellular aspects of neural function, plasticity, aging or disease. In addition to analyses in the traditional genetic-model organisms, C. elegans, Drosophila, mouse and the zebrafish, the Journal encourages submission of neurogenetic investigations performed in organisms not easily amenable to experimental genetics. Such investigations might, for instance, describe behavioral differences deriving from genetic variation within a species, or report human disease studies that provide exceptional insights into biological mechanisms
期刊最新文献
Epilepsy genetics in the paediatric population of the Eastern Anatolia region of Turkey. Targeted deletion of olfactory receptors in D. melanogaster via CRISPR/Cas9-mediated LexA knock-in. The initial years of the Cold Spring Harbor Laboratory summer course on the neurobiology of Drosophila. Clinical potential of epigenetic and microRNA biomarkers in PTSD. Molecular analysis of SMN2, NAIP, and GTF2H2 gene deletions and relationships with clinical subtypes of spinal muscular atrophy.
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