N6-Methyladenosine methylation modification in breast cancer: current insights.

IF 6.1 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Journal of Translational Medicine Pub Date : 2024-10-28 DOI:10.1186/s12967-024-05771-x
Guangwen Zhang, Chen Cheng, Xinle Wang, Shiming Wang
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Abstract

Breast cancer is the most common cancer type among women. Despite advanced treatment strategies, some patients still face challenges in disease control, prompting the exploration of new therapeutic approaches. N6-Methyladenosine (m6A) methylation modification regulates RNA and plays a crucial role in various tumor biological processes, closely linked to breast cancer occurrence, development, prognosis, and treatment. M6A regulators impact breast cancer progression, development, and drug resistance by modulating RNA metabolism and tumor-related pathways. Researchers have begun to understand the regulatory mechanisms of m6A methylation in breast cancer. This paper discusses the roles of m6A regulators in breast cancer progression, prognosis, and treatment, offering new perspectives for breast cancer diagnosis and treatment.

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乳腺癌中的 N6-甲基腺苷甲基化修饰:当前的见解。
乳腺癌是女性最常见的癌症类型。尽管治疗策略先进,但一些患者在疾病控制方面仍面临挑战,这促使人们探索新的治疗方法。N6-甲基腺苷(m6A)甲基化修饰调控 RNA,在各种肿瘤生物学过程中发挥着至关重要的作用,与乳腺癌的发生、发展、预后和治疗密切相关。M6A 调节因子通过调节 RNA 代谢和肿瘤相关通路,对乳腺癌的进展、发展和耐药性产生影响。研究人员已开始了解乳腺癌中 m6A 甲基化的调控机制。本文讨论了 m6A 调节因子在乳腺癌进展、预后和治疗中的作用,为乳腺癌的诊断和治疗提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Translational Medicine
Journal of Translational Medicine 医学-医学:研究与实验
CiteScore
10.00
自引率
1.40%
发文量
537
审稿时长
1 months
期刊介绍: The Journal of Translational Medicine is an open-access journal that publishes articles focusing on information derived from human experimentation to enhance communication between basic and clinical science. It covers all areas of translational medicine.
期刊最新文献
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