The association between age at natural menopause and risk of asthma among postmenopausal women from the Canadian Longitudinal Study on Aging.

IF 2.8 3区医学 Q1 OBSTETRICS & GYNECOLOGY Menopause: The Journal of The North American Menopause Society Pub Date : 2024-10-29 DOI:10.1097/GME.0000000000002443

Durmalouk Kesibi, Michael Rotondi, Heather Edgell, Hala Tamim

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Abstract

Objective: This study aimed to investigate the association between age at natural menopause and incidence of asthma among postmenopausal Canadian women.

Methods: Women between the ages of 45-85 yr were followed for a 10-yr period. Analysis was restricted to naturally postmenopausal women who are nonsmokers and did not have asthma prior to menopause. Age at natural menopause was examined using the following categories: 40-44, 45-49, 50-54 (reference), and ≥55. Survival analysis was utilized to determine time to onset of asthma. Multivariable Cox regression analysis was performed to assess the relationship between age at natural menopause and asthma after adjusting for covariates.

Results: The multivariable Cox regression analysis showed a 30% decreased risk of asthma in women with age at natural menopause of 40-44 yr compared with age at natural menopause of 50-54 yr with a hazard ratio of 0.7 (95% confidence interval: 0.49-0.95).

Conclusions: Women with later ages at natural menopause may be at increased risk for asthma.

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加拿大老龄化纵向研究》（Canadian Longitudinal Study on Aging）中绝经后妇女自然绝经年龄与哮喘风险之间的关系。

目的：本研究旨在调查加拿大绝经后妇女自然绝经年龄与哮喘发病率之间的关系：本研究旨在调查加拿大绝经后妇女的自然绝经年龄与哮喘发病率之间的关系：方法：对年龄在 45-85 岁之间的妇女进行为期 10 年的跟踪调查。分析对象仅限于自然绝经后、不吸烟且绝经前未患哮喘的女性。自然绝经年龄按以下类别进行研究：40-44岁、45-49岁、50-54岁（参考）和≥55岁。采用生存分析法确定哮喘发病时间。在调整协变量后，进行了多变量 Cox 回归分析，以评估自然绝经年龄与哮喘之间的关系：多变量考克斯回归分析显示，自然绝经年龄为 40-44 岁的女性患哮喘的风险比自然绝经年龄为 50-54 岁的女性降低了 30%，危险比为 0.7（95% 置信区间：0.49-0.95）：结论：自然绝经年龄较晚的女性患哮喘的风险可能会增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Menopause: The Journal of The North American Menopause Society 医学-妇产科学

CiteScore

5.40

自引率

7.40%

发文量

330

审稿时长

3-8 weeks

期刊介绍： Menopause, published monthly, provides a forum for new research, applied basic science, and clinical guidelines on all aspects of menopause. The scope and usefulness of the journal extend beyond gynecology, encompassing many varied biomedical areas, including internal medicine, family practice, medical subspecialties such as cardiology and geriatrics, epidemiology, pathology, sociology, psychology, anthropology, and pharmacology. This forum is essential to help integrate these areas, highlight needs for future research, and enhance health care.

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