[Polymorphism of RAAS genes in patients with COVID-19: comparison with frequency in population and relationship with severity of course].

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Terapevticheskii Arkhiv Pub Date : 2024-10-10 DOI:10.26442/00403660.2024.09.202849

A E Bragina, Y N Rodionova, E S Ogibenina, A S Fomin, V I Podzolkov

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Abstract

Aim: Evaluation of genes polymorphisms frequencies of angiotensinogen (AGT), angiotensin converting enzyme type 1 (ACE1) and angiotensin II receptors type 1 (AGTR1) and type 2 (AGTR2) in patients admitted with coronavirus disease (COVID-19) and its association the severity of severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2).

Materials and methods: The study included 100 patients admitted to the hospital with a laboratory-confirmed diagnosis of COVID-19. All patients were identified with alleles and genotypes of polymorphic markers rs4762 of the AGT gene, rs1799752 of the ACE1 gene, rs5186 of the AGTR1 gene and rs1403543 of the AGTR2 gene. The frequencies of each polymorphisms were compared with population. Statistical processing was performed using the Statistica 8.0 software package.

Results: In evaluated cohort there was higher frequency of D-allele ACE1 rs1799752 compared to population. Depending on the availability of criteria for the severity of coronavirus infection, 44 (44%) patients were diagnosed with severe, 56 (56%) with moderate course. The groups did not significantly differ in age, gender, cardiovascular risk factors and comorbid pathology. In the groups with severe and moderate course, the same distribution of genotypes and alleles of AGT rs4762, AGTR2 rs1403543 and ACE1 rs1799752 was revealed. For the I/D alleles of the ACE1 rs1799752 gene, a significant deviation from the papulation was found in both the group of severe and moderate COVID-19. In the group with a severe course of the disease, a higher frequency of the mutant C-allele of the AGTR1 rs5186 gene was detected. In the same group, a deviation in the frequency ratio of A and C of the AGTR1 rs5186 alleles from Hardy-Weinberg Equilibrium was found. When calculating the risk of severe COVID-19 in the presence of the C-allele compared with the A-allele, an odds ratio 2.092 (95% confidence interval 1.066-4.108) was obtained.

Conclusion: The data obtained suggest that the genes polymorphisms of the components of renin-angiotensin-aldosterone system, namely D-allele of ACE1 rs1799752 and C-allele of AGTR1 rs5186, may make it possible to identify groups of patients predisposed to the development of more severe COVID-19.

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[COVID-19患者RAAS基因的多态性：与人群频率的比较及与病程严重程度的关系]。

目的：评估冠状病毒病（COVID-19）患者血管紧张素原（AGT）、血管紧张素转换酶1型（ACE1）、血管紧张素II受体1型（AGTR1）和2型（AGTR2）的基因多态性频率及其与严重急性呼吸系统综合征相关冠状病毒-2（SARS-CoV-2）严重程度的关系：研究对象包括 100 名经实验室确诊为 COVID-19 的住院患者。对所有患者的 AGT 基因 rs4762、ACE1 基因 rs1799752、AGTR1 基因 rs5186 和 AGTR2 基因 rs1403543 多态性标记的等位基因和基因型进行了鉴定。各多态性的频率与人群进行了比较。统计处理使用 Statistica 8.0 软件包进行：结果：在接受评估的队列中，D-等位基因 ACE1 rs1799752 的频率高于人群。根据冠状病毒感染严重程度的标准，44（44%）名患者被诊断为重度感染，56（56%）名患者被诊断为中度感染。两组患者在年龄、性别、心血管风险因素和合并病症方面没有明显差异。在重度和中度病程组中，AGT rs4762、AGTR2 rs1403543 和 ACE1 rs1799752 的基因型和等位基因分布相同。至于 ACE1 rs1799752 基因的 I/D 等位基因，在重度和中度 COVID-19 组中都发现与乳头状明显偏离。在重度病程组中，检测到 AGTR1 rs5186 基因的突变 C 等位基因频率较高。在同一组中，AGTR1 rs5186 等位基因的 A 和 C 的频率比偏离了哈代-温伯格平衡（Hardy-Weinberg Equilibrium）。在计算存在 C 等位基因与 A 等位基因时罹患严重 COVID-19 的风险时，得出的几率比为 2.092（95% 置信区间为 1.066-4.108）：所获数据表明，肾素-血管紧张素-醛固酮系统成分的基因多态性，即 ACE1 的 D-等位基因 rs1799752 和 AGTR1 的 C-等位基因 rs5186，可用于识别易患更严重 COVID-19 的患者群体。

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来源期刊

Terapevticheskii Arkhiv 医学-医学：内科

CiteScore

1.40

自引率

33.30%

发文量

171

审稿时长

3-8 weeks

期刊介绍： Терапевтический архив The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal. Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases. The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists. The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal. The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory. The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations. By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE). The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.