Evaluating stiffness of gastric wall using laser resonance frequency analysis for gastric cancer.

IF 5.7 2区 医学 Q1 Medicine Cancer Science Pub Date : 2024-10-28 DOI:10.1111/cas.16383
Tasuku Furube, Daisuke Nakashima, Satoru Matsuda, Katsuhiro Mikami, Takuto Hatakeyama, Masashi Takeuchi, Kazumasa Fukuda, Akihisa Ueno, Hajime Okita, Hirofumi Kawakubo, Masaya Nakamura, Takeo Nagura, Yuko Kitagawa
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Abstract

Tumor stiffness is drawing attention as a novel axis that is orthogonal to existing parameters such as pathological examination. We developed a new diagnostic method that focuses on differences in stiffness between tumor and normal tissue. This study comprised a clinical application of laser resonance frequency analysis (L-RFA) for diagnosing gastric cancer. L-RFA allows for precise and contactless evaluation of tissue stiffness. We used a laser to create vibrations on a sample's surface that were then measured using a vibrometer. The data were averaged and analyzed to enhance accuracy. In the agarose phantom experiments, a clear linear correlation was observed between the Young's modulus of the phantoms (0.34-0.71 MPa) and the summation of normalized vibration peaks (Score) in the 1950-4050 Hz range (R2 = 0.93145). Higher Young's moduli also resulted in lower vibration peaks at the excitation frequency, signal-to-noise (S/N) ratios, and harmonic peaks. We also conducted L-RFA measurements on gastric cancer specimens from two patients who underwent robot-assisted distal gastrectomy. Our results revealed significant waveform differences between tumor and normal regions, similar to the findings in agarose phantoms, with tumor regions exhibiting lower vibration peaks at the excitation frequency, S/N ratios, and harmonic peaks. Statistical analysis confirmed significant differences in the score between normal and tumor regions (p = 0.00354). L-RFA was able to assess tumor stiffness and holds great promise as a noninvasive diagnostic tool for gastric cancer.

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利用激光共振频率分析评估胃癌胃壁硬度
肿瘤僵硬度作为一种与病理检查等现有参数正交的新轴心,正在引起人们的关注。我们开发了一种新的诊断方法,重点关注肿瘤和正常组织之间的硬度差异。这项研究包括激光共振频率分析(L-RFA)在胃癌诊断中的临床应用。激光共振频率分析可对组织硬度进行精确的非接触式评估。我们使用激光在样本表面产生振动,然后使用测振仪进行测量。对数据进行平均和分析,以提高准确性。在琼脂糖模型实验中,我们观察到模型的杨氏模量(0.34-0.71 兆帕)与 1950-4050 赫兹范围内归一化振动峰值(Score)的总和之间存在明显的线性相关(R2 = 0.93145)。杨氏模量越大,激励频率的振动峰值、信噪比和谐波峰值也越低。我们还对两名接受机器人辅助远端胃切除术的胃癌标本进行了 L-RFA 测量。我们的结果表明,肿瘤区域和正常区域的波形存在明显差异,这与琼脂糖模型中的结果类似,肿瘤区域在激励频率、信噪比和谐波峰上都表现出较低的振动峰。统计分析证实,正常区域和肿瘤区域的得分存在明显差异(p = 0.00354)。L-RFA 能够评估肿瘤的硬度,有望成为胃癌的无创诊断工具。
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来源期刊
Cancer Science
Cancer Science ONCOLOGY-
CiteScore
9.90
自引率
3.50%
发文量
406
审稿时长
17 weeks
期刊介绍: Cancer Science (formerly Japanese Journal of Cancer Research) is a monthly publication of the Japanese Cancer Association. First published in 1907, the Journal continues to publish original articles, editorials, and letters to the editor, describing original research in the fields of basic, translational and clinical cancer research. The Journal also accepts reports and case reports. Cancer Science aims to present highly significant and timely findings that have a significant clinical impact on oncologists or that may alter the disease concept of a tumor. The Journal will not publish case reports that describe a rare tumor or condition without new findings to be added to previous reports; combination of different tumors without new suggestive findings for oncological research; remarkable effect of already known treatments without suggestive data to explain the exceptional result. Review articles may also be published.
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