Assessment of Knowledge, Attitude, and Practice of Therapeutic Drug Monitoring Among Hospital Pharmacists in Saudi Arabia

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL International Journal of Clinical Practice Pub Date : 2024-10-25 DOI:10.1155/2024/3435718

Sharaf E. Sharaf, Abdulhamid Dahlawi, Abdulrahman Alhajjaji, Afnan Alqurashi, Mmyada Albarakati, Mustafa Badawi, Nouf Alhassani, Omar Alshareef, Sultan Bajawi, Walid Alsufyani, Widad Alfahmi, Yomna Qudus, Anas Shamsi

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Abstract

Objective: Optimal therapeutic drug monitoring (TDM), including clinical pharmacokinetics, appropriate interpretation, and dose adjustment of drugs, is required to effectively monitor specific therapeutic drugs. Hospital pharmacists (HPs), being the most qualified healthcare professionals to implement TDM, must understand its applications to determine and adjust drug doses and avoid adverse drug reactions and toxicity. Therefore, in this knowledge, attitude, and practice (KAP) study, we assessed TDM level among HPs in Saudi Arabia.

Methods: This cross-sectional study was conducted with 414 HPs in the Makkah region with a valid pharmacy license from the Saudi Commission for Health Specialties. An overall score of 50% or higher of the total responses in each section was considered good, whereas an overall score lower than 50% was considered poor. Categorical data are expressed as frequency and percentage. Correlations were measured using Pearson’s correlation coefficient (r).

Results: The TDM-KAP levels of the participants were 50%, 80%, and 62% for KAP, respectively. Significant positive linear correlations were found between knowledge and attitude, knowledge and practice, attitude and practice, knowledge and classification, practice and classification, practice and experience, and knowledge and experience. The participants showed acceptable knowledge and practice of TDM levels with elevated attitude levels.

Conclusion: As a lack of TDM knowledge directly contributes to reduced practice levels, increasing TDM knowledge and practice by introducing more intensive pharmaceutical programs that illustrate TDM clinical applications in hospitals is recommended, which will enhance HP integration.

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沙特阿拉伯医院药剂师对治疗药物监测的知识、态度和实践的评估

目的：最佳治疗药物监测（TDM），包括临床药代动力学、适当解释和药物剂量调整，是有效监测特定治疗药物的必要条件。医院药剂师（HPs）是最有资格实施 TDM 的医疗保健专业人员，必须了解其应用，以确定和调整药物剂量，避免药物不良反应和毒性。因此，在这项知识、态度和实践（KAP）研究中，我们评估了沙特阿拉伯医院药剂师的 TDM 水平。研究方法这项横断面研究的对象是麦加地区 414 名持有沙特卫生专业委员会颁发的有效药房执照的保健医生。每个部分的总分达到或超过总分的 50%，即为良好；总分低于 50%，即为较差。分类数据以频率和百分比表示。相关性采用皮尔逊相关系数 (r) 进行测量。结果参与者的 TDM-KAP 水平分别为 50%、80% 和 62%。在知识与态度、知识与实践、态度与实践、知识与分类、实践与分类、实践与经验、知识与经验之间发现了显著的正线性相关。参与者对行车需求管理的知识和实践水平均可接受，但态度水平较高。结论由于 TDM 知识的缺乏直接导致了实践水平的降低，因此建议通过在医院中引入更多说明 TDM 临床应用的强化制药项目来增加 TDM 的知识和实践，这将加强 HP 整合。

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.