Sensitive and Cost-Effective Tools in the Detection of Ovarian Cancer Biomarkers

IF 3 Q2 CHEMISTRY, ANALYTICAL Analytical science advances Pub Date : 2024-10-24 DOI:10.1002/ansa.202400029
Anis Elhami, Ahmad Mobed, Reza Soleimany, Yalda Yazdani, Esmat Sadat Kazemi, Mahya Mohammadi, Hossein Saffarfar
{"title":"Sensitive and Cost-Effective Tools in the Detection of Ovarian Cancer Biomarkers","authors":"Anis Elhami,&nbsp;Ahmad Mobed,&nbsp;Reza Soleimany,&nbsp;Yalda Yazdani,&nbsp;Esmat Sadat Kazemi,&nbsp;Mahya Mohammadi,&nbsp;Hossein Saffarfar","doi":"10.1002/ansa.202400029","DOIUrl":null,"url":null,"abstract":"<p>Women diagnosed with late-stage ovarian cancer suffer a very high rate of mortality. Accordingly, it is imperative to detect and diagnose the disease as early as possible in its development. Achievement of this aim implies relatively large-scale screening of women at an age of clinical significance through assay of biomarkers for disease present in blood or serum. Biosensor detection offers an attractive technology for the automated detection of such species. Among several biomarkers that have been identified that are present in patients with ovarian cancer, the only one that is commonly tested for in clinical use is cancer antigen 125, which is considered to be a poor biomarker for the disease. Here, we describe several biosensors that developed in the past decade for the detection of ovarian cancer biomarkers such as CA125, human epididymis protein 4 (HE4) and apolipoprotein A1. The challenges presented by the fabrication of biosensor devices for detecting ovarian cancer and the limited number of biosensors developed for this purpose are discussed.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"5 9-10","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202400029","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical science advances","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ansa.202400029","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0

Abstract

Women diagnosed with late-stage ovarian cancer suffer a very high rate of mortality. Accordingly, it is imperative to detect and diagnose the disease as early as possible in its development. Achievement of this aim implies relatively large-scale screening of women at an age of clinical significance through assay of biomarkers for disease present in blood or serum. Biosensor detection offers an attractive technology for the automated detection of such species. Among several biomarkers that have been identified that are present in patients with ovarian cancer, the only one that is commonly tested for in clinical use is cancer antigen 125, which is considered to be a poor biomarker for the disease. Here, we describe several biosensors that developed in the past decade for the detection of ovarian cancer biomarkers such as CA125, human epididymis protein 4 (HE4) and apolipoprotein A1. The challenges presented by the fabrication of biosensor devices for detecting ovarian cancer and the limited number of biosensors developed for this purpose are discussed.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
检测卵巢癌生物标记物的灵敏而经济的工具
被诊断为晚期卵巢癌的妇女死亡率非常高。因此,必须在疾病发展初期尽早发现和诊断。要实现这一目标,就必须通过检测血液或血清中的疾病生物标志物,对处于临床重要年龄段的妇女进行相对大规模的筛查。生物传感器检测为自动检测此类物质提供了一种极具吸引力的技术。在已确定的卵巢癌患者体内存在的几种生物标记物中,临床上通常检测的只有癌症抗原 125,它被认为是一种不良的疾病生物标记物。在此,我们介绍了过去十年中开发的几种用于检测卵巢癌生物标志物(如 CA125、人附睾蛋白 4(HE4)和载脂蛋白 A1)的生物传感器。我们还讨论了制造用于检测卵巢癌的生物传感器设备所面临的挑战,以及为此开发的生物传感器数量有限的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
4.60
自引率
0.00%
发文量
0
期刊最新文献
Emerging Scientists in Analytical Sciences: Zhuoheng Zhou Sensitive and Cost-Effective Tools in the Detection of Ovarian Cancer Biomarkers Preprocessing of spectroscopic data to highlight spectral features of materials Bioactive Potential of the Sulfated Exopolysaccharides From the Brown Microalga Halamphora sp.: Antioxidant, Antimicrobial, and Antiapoptotic Profiles Effect of orange fruit peel extract concentration on the synthesis of zinc oxide nanoparticles
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1