Yarit Wiggerts , Annabel van der Weide , Evan Markidis , Joke M. Dijk , Vincent J.J. Odekerken , Maarten Bot , Pepijn van den Munckhof , P. Rick Schuurman , Rob M.A. de Bie , Martijn Beudel
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Abstract
Background
Deep brain stimulation (DBS) for Parkinson’s disease (PD), essential tremor (ET), and dystonia is a well-established treatment option. The correlation between motor symptom improvement and effect on disability is inconclusive.
Objectives
To assess the correlation between DBS-induced improvements of motor symptoms and disability for PD, ET and dystonia.
Methods
Disability and motor scores were obtained before and six to twelve months after surgery for 324 PD, 35 ET and 40 dystonia patients.
Results
There was a modest and significant correlation for PD (Rho=0.284, p < 0.001), a substantial and significant correlation for ET (Rho=0.542, p < 0.001) and no correlation for dystonia (Rho=0.238, p = 0.138) between motor score and disability improvement.
Conclusions
The effect of DBS on motor symptoms and disability is not uniformly for dystonia. Possible reasons for this are that the scales used might not be responsive or other symptoms than motor symptoms might have a greater impact on disability.
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