{"title":"An entry to spiro-fused sultams via electrochemical brominative ipso-annulation of N-aryl alkynyl sulphonamides","authors":"Chada Raji Reddy , Maramoni Shivudu , Anjali Rathaur","doi":"10.1016/j.tetlet.2024.155330","DOIUrl":null,"url":null,"abstract":"<div><div>Synthesis of cyclohexadienone spiro-fused sultams is established through electrochemical brominative intramolecular <em>ipso</em>-annulation of <em>N-</em>aryl alkynyl sulphonamides. A range of aryl/heteroarylated-alkynyl sulphonamides are suitable under external oxidant-free electrochemical conditions. Lithium bromide is used as bromine source in this domino bromination/<em>ipso</em>-cyclization, leading to the corresponding bromo spiro-sultams in good yields.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"152 ","pages":"Article 155330"},"PeriodicalIF":1.5000,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924004258","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/22 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Synthesis of cyclohexadienone spiro-fused sultams is established through electrochemical brominative intramolecular ipso-annulation of N-aryl alkynyl sulphonamides. A range of aryl/heteroarylated-alkynyl sulphonamides are suitable under external oxidant-free electrochemical conditions. Lithium bromide is used as bromine source in this domino bromination/ipso-cyclization, leading to the corresponding bromo spiro-sultams in good yields.
期刊介绍：
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.
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