José A. Ferreira , Mario Grassi , Elías Gudiño , Paula de Oliveira
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引用次数: 0
Abstract
In this paper we present a novel mathematical model to describe the permeation of a fluid through a polymeric matrix, loaded with drug molecules, followed by its subsequent desorption. Both phenomena are enhanced by temperature. We deduce energy estimates and stability estimates for the weak solution of the model, showing that this solution of the problem is stable in bounded time intervals. Numerical simulations illustrate how the coupling effects, of viscoelastic properties and thermal external assistance, can have a central role in the design of drug delivery devices.
期刊介绍：
The Journal of Computational and Applied Mathematics publishes original papers of high scientific value in all areas of computational and applied mathematics. The main interest of the Journal is in papers that describe and analyze new computational techniques for solving scientific or engineering problems. Also the improved analysis, including the effectiveness and applicability, of existing methods and algorithms is of importance. The computational efficiency (e.g. the convergence, stability, accuracy, ...) should be proved and illustrated by nontrivial numerical examples. Papers describing only variants of existing methods, without adding significant new computational properties are not of interest.
The audience consists of: applied mathematicians, numerical analysts, computational scientists and engineers.
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