Optimization and control in rubella transmission dynamics: A boundedness-preserving numerical model with vaccination

Samiullah Salim , Fazal Dayan , Muhammad Aziz ur Rehman , Husam A. Neamah
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Abstract

Rubella is an infectious disease that can spread globally. It spreads in the subtropics as well as the tropics. Although it is commonly thought to be a non-fatal condition, there are several circumstances in which it can be fatal. Pregnant women infected with the Rubella virus face a high risk of fetal development. The main goal of this study is to look into a model for the spread of Rubella while considering a vaccination campaign as a control measure. The positivity and boundedness of the re-infection rubella transmission and vaccination model are investigated. The local and global stability of the equilibrium points is examined. The sensitivity of parameters is also investigated. Three different techniques forward Euler, RK-4, and non-standard finite difference (NSFD) method are developed for the numerical solution, and their simulation results are examined. Among these three, the NSFD method is superior due to its convergence and positive behavior for all step size values. For some values of the step size, the other two techniques failed to produce positivity and convergent solutions. Analytically, the proposed model's convergence, positivity, boundedness, and consistency are investigated. Finally, the impact of the Rubella vaccine on infected populations has been examined, revealing that vaccination is one of the most effective ways to prevent rubella transmission.
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风疹传播动态中的优化与控制:带疫苗接种的有界保护数值模型
风疹是一种可在全球传播的传染病。它既可在亚热带地区传播,也可在热带地区传播。虽然人们普遍认为这种疾病不会致命,但在某些情况下,它可能会致命。感染风疹病毒的孕妇面临着胎儿发育的高风险。本研究的主要目的是在考虑将疫苗接种活动作为控制措施的同时,研究风疹传播的模型。研究了再感染风疹传播和疫苗接种模型的实在性和有界性。研究了平衡点的局部和全局稳定性。还研究了参数的敏感性。为数值求解开发了三种不同的前向欧拉法、RK-4 法和非标准有限差分法(NSFD),并对其模拟结果进行了检验。在这三种方法中,非标准有限差分法因其在所有步长值下的收敛性和正行为而更胜一筹。对于某些步长值,其他两种技术无法产生正向和收敛解。分析研究了所提出模型的收敛性、正向性、有界性和一致性。最后,研究了风疹疫苗对受感染人群的影响,发现接种疫苗是预防风疹传播的最有效方法之一。
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来源期刊
Informatics in Medicine Unlocked
Informatics in Medicine Unlocked Medicine-Health Informatics
CiteScore
9.50
自引率
0.00%
发文量
282
审稿时长
39 days
期刊介绍: Informatics in Medicine Unlocked (IMU) is an international gold open access journal covering a broad spectrum of topics within medical informatics, including (but not limited to) papers focusing on imaging, pathology, teledermatology, public health, ophthalmological, nursing and translational medicine informatics. The full papers that are published in the journal are accessible to all who visit the website.
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