A smartphone-assisted chromogenic and fluorogenic dual-channel sensor for specific determination of toxic Pb2+ ions with multifaceted applications

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC Tetrahedron Pub Date : 2024-10-21 DOI:10.1016/j.tet.2024.134316

Haiyan Xu , Wenlong Qin , Junyu Zhu , Ying-Guo Liu

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Abstract

Heavy metal pollutants, such as Pb²⁺ ions, pose a substantial hazard to human health and ecosystems, and it was of great significance to develop cost-effective and portable techniques for online and visual detection of Pb²⁺. Herein, we fabricated a novel chromogenic and fluorogenic dual-channel sensor NQA through a Schiff base reaction involving a dicyanoisophorone derivative and isoniazid, enabling effective detection of Pb²⁺ ions. Upon complexation with Pb²⁺ ions at a 1:1 M ratio, the fluorescence intensity of NQA exhibited a remarkable enhancement. The naked-eye colorimetric detection utilizing NQA demonstrated a distinct color change to specific Pb²⁺ ions concentration from yellow to light pink. Based on this principle, a smartphone-assisted sensing platform was developed for visual and high-quality identification of Pb²⁺ in real samples. The UV binding constant for Pb²⁺ ions was determined to be 1.84 × 10⁵ M⁻¹, with a detection limit of 0.38 μM. Furthermore, the versatility of NQA extended to applications in naked-eye test paper experiments, the detection of Pb²⁺ ions in real water samples and living cells, showcasing its potential for environmental and biological monitoring.

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用于特异性测定有毒 Pb2+ 离子的智能手机辅助显色和荧光双通道传感器的多方面应用

以 Pb2+ 离子为代表的重金属污染物对人类健康和生态系统造成了严重危害，因此开发经济、便携的 Pb2+ 在线可视检测技术具有重要意义。在此，我们通过二氰异佛尔酮衍生物与异烟肼的希夫碱反应，制备了一种新型发色性和发荧光性双通道传感器 NQA，从而实现了对 Pb2+ 离子的有效检测。以 1:1 M 的比例与 Pb2+ 离子络合后，NQA 的荧光强度显著增强。利用 NQA 进行的肉眼比色检测显示，特定的 Pb2+ 离子浓度会产生从黄色到浅粉色的明显颜色变化。基于这一原理，我们开发了一种智能手机辅助传感平台，用于对实际样品中的 Pb2+ 进行高质量的肉眼识别。经测定，Pb2+ 离子的紫外结合常数为 1.84 × 105 M-1，检测限为 0.38 μM。此外，NQA 的多功能性还扩展到了裸眼试纸实验、真实水样和活细胞中 Pb2+ 离子的检测等方面的应用，展示了其在环境和生物监测方面的潜力。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.

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