Identification of genes related to fatty acid metabolism in type 2 diabetes mellitus

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry and Biophysics Reports Pub Date : 2024-10-22 DOI:10.1016/j.bbrep.2024.101849

Ji Yang , Yikun Zhou , Jiarui Zhang , Yongqin Zheng , Jundong He

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Abstract

Aim

Fatty acid metabolism is pivotal for lipid synthesis, cellular signaling, and maintaining cell membrane integrity. However, its diagnostic significance in type 2 diabetes mellitus (T2DM) remains unclear.

Materials and methods

Three datasets and fatty acid metabolism-related genes were retrieved. Differential expression analysis, WGCNA, machine learning algorithms, diagnostic analysis, and validation were employed to identify key feature genes. Functional analysis, ceRNA network construction, immune microenvironment assessment, and drug prediction were conducted to explore the underlying molecular mechanisms.

Results

Six feature genes were identified with strong diagnostic performance and were involved in processes such as ribosome function and fatty acid metabolism. Immune cells, including dendritic cells, eosinophils, and neutrophils, may play a role in the progression of T2DM. ceRNA and drug-target network analysis revealed potential interactions, such as RP11-miR-29a-YTHDF3 and BPA-MSANTD1. The expression patterns of the feature genes, except for YTHDF3, were consistently upregulated in T2DM, aligning with trends observed in the training set.

Conclusion

This study investigated the potential molecular mechanisms of six fatty acid metabolism-related genes in T2DM, offering valuable insights that may guide future research and therapeutic development.

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鉴定与 2 型糖尿病脂肪酸代谢有关的基因

目的脂肪酸代谢对脂质合成、细胞信号传导和维持细胞膜完整性至关重要。材料与方法检索了三个数据集和脂肪酸代谢相关基因。采用差异表达分析、WGCNA、机器学习算法、诊断分析和验证来确定关键特征基因。结果发现了六个具有较强诊断能力的特征基因，它们参与了核糖体功能和脂肪酸代谢等过程。ceRNA和药物靶点网络分析发现了潜在的相互作用，如RP11-miR-29a-YTHDF3和BPA-MSANTD1。除 YTHDF3 外，其他特征基因的表达模式在 T2DM 中持续上调，与训练集中观察到的趋势一致。

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.