Mixed silicates with three-dimensional micro-architecture toward accelerate the antibacterial hemostatic effects in wound healing

Abstract

Silicates with the antibacterial hemostatic effects used in wound healing that could be served as antibiotic alternatives to traditional biomedicines. Mixed silicates containing two or more silicates with different morphologies exhibit an accelerated antibacterial hemostatic effects (e.g., the antibacterial rate toward kaolinite-montmorillonite against E. coli and S. aureus reached a maximum value of 59.14 ± 1.46 % and 91.83 ± 0.85 %, the blood clotting index and the hemostatic time toward kaolinite-montmorillonite reached a maximum value of 4.06 ± 1.56 % and 165.67 ± 6.13 s), that could be attributed to the individual silicate’s intrinsic antibacterial hemostatic effects arising from the silicate’s surface/edge charge and the constructed three-dimensional micro-architectural characteristics arising from the individual silicate’s loose stack state in mixed silicates. Besides, those ineffective antibacterial hemostatic effects were attributed to the unsuccessful three-dimensional micro-architectural construction originated from the silicate’s unreasonable mass ratio. The current findings illustrated that mixed silicates with an accelerated antibacterial hemostatic effects could be used in wound healing with taking into account biomedical functional module collocation and actual scenario orientation.