Bioconjugated Antibody-Trojan Immune Converter Enhance Cancer Immunotherapy with Minimized Toxicity by Programmed Two-Step Immunomodulation of Myeloid Cells (Adv. Healthcare Mater. 27/2024)

IF 10 2区 医学 Q1 ENGINEERING, BIOMEDICAL Advanced Healthcare Materials Pub Date : 2024-10-28 DOI:10.1002/adhm.202470171
Soyoung Park, Seung Mo Jin, Suhyeon Kim, Ju Hee Cho, JungHyub Hong, Yong-Soo Bae, Yong Taik Lim
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Abstract

Antibody-Trojan Immune Converter

In article 2401270 by Yong Taik Lim and co-worker, a programmed two-step activation strategy is suggested to enhance cancer immunotherapy with minimized systemic toxicities via Antibody-Trojan Immune Converter Conjugates that specifically targets myeloid cells by anti-SIRPα followed by reactivation of transiently inactivated Trojan TLR7/8 agonist after antibody-mediated endocytosis.

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生物共轭抗体-特洛伊免疫转换器通过对髓系细胞进行程序化两步免疫调节,以最小的毒性增强癌症免疫疗法(Adv. Healthcare Mater.)
抗体-特洛伊免疫转换器在 Yong Taik Lim 及其合作者发表的 2401270 号文章中,提出了一种程序化的两步激活策略,通过抗体-特洛伊免疫转换器共轭物增强癌症免疫疗法,并将全身毒性降到最低,该共轭物通过抗 SIRPα 特异性靶向髓系细胞,然后在抗体介导的内吞作用后重新激活瞬时失活的特洛伊 TLR7/8 激动剂。
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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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