Clinical Significance of FAM83G in Breast Cancer: Association With Triple-negative Subtype and Prognosis.

IF 1.6 4区 医学 Q4 ONCOLOGY Anticancer research Pub Date : 2024-11-01 DOI:10.21873/anticanres.17313
Takako Ikeda, Chikako Kanno Honda, Sasagu Kurozumi, Takehiko Yokobori, Ayaka Katayama, Kei Masuda, Tetsunari Oyama, Kyoichi Kaira, Jun Horiguchi, Ken Shirabe, Takaaki Fujii
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Abstract

Background/aim: Family with sequence similarity 83 member G (FAM83G) plays an important role in cancer aggressiveness and patients' prognosis across various types of cancer. However, the association of FAM83G protein expression in breast cancer with clinicopathologic factors, breast cancer subtypes, and prognosis is not well characterized. This study aimed to elucidate the clinical significance of FAM83G protein expression in breast cancer.

Materials and methods: Immunohistochemistry was employed to examine FAM83G protein expression in 75 breast cancer tissues, assessing its potential as a biomarker for breast cancer patients. The Kaplan-Meier plotter was used to estimate the correlation between FAM83G mRNA expression and survival outcomes in TNBC patients.

Results: FAM83G protein was predominantly localized in the cytoplasm of breast cancer cells, exhibiting uniform expression throughout tumor tissues. FAM83G expression was significantly higher in cancerous areas compared to non-cancerous areas. High FAM83G expression was more prevalent in triple-negative breast cancer (TNBC) cases than in hormone receptor-positive cases. Although high FAM83G protein expression did not significantly impact prognosis in our cohort, a large-scale database analysis revealed an association between high FAM83G expression and poor prognosis in TNBC cases.

Conclusion: This study demonstrates an association between high FAM83G expression in breast cancer tissues and TNBC. FAM83G may serve as a promising biomarker and therapeutic target for breast cancer patients.

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FAM83G 在乳腺癌中的临床意义:与三阴性亚型和预后的关系
背景/目的:序列相似性家族 83 成员 G(FAM83G)在各类癌症的侵袭性和患者预后中发挥着重要作用。然而,FAM83G 蛋白在乳腺癌中的表达与临床病理因素、乳腺癌亚型和预后的关系还不十分明确。本研究旨在阐明乳腺癌中 FAM83G 蛋白表达的临床意义:采用免疫组织化学方法检测 75 例乳腺癌组织中 FAM83G 蛋白的表达,评估其作为乳腺癌患者生物标志物的潜力。用Kaplan-Meier绘图仪估计FAM83G mRNA表达与TNBC患者生存结果之间的相关性:结果:FAM83G蛋白主要定位于乳腺癌细胞的胞浆中,在整个肿瘤组织中均呈均匀表达。与非癌区相比,癌区的 FAM83G 表达明显较高。FAM83G 的高表达在三阴性乳腺癌(TNBC)病例中比在激素受体阳性病例中更为普遍。虽然在我们的队列中,FAM83G蛋白的高表达对预后没有明显影响,但一项大规模数据库分析显示,在TNBC病例中,FAM83G的高表达与预后不良有关:本研究表明,乳腺癌组织中 FAM83G 的高表达与 TNBC 存在关联。结论:本研究表明,FAM83G在乳腺癌组织中的高表达与TNBC存在关联,FAM83G可作为乳腺癌患者的一种有前景的生物标记物和治疗靶点。
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来源期刊
Anticancer research
Anticancer research 医学-肿瘤学
CiteScore
3.70
自引率
10.00%
发文量
566
审稿时长
2 months
期刊介绍: ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.
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