Intricate roles of estrogen and estrogen receptors in digestive system cancers: a systematic review.

IF 5.6 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Cancer Biology & Medicine Pub Date : 2024-10-30 DOI:10.20892/j.issn.2095-3941.2024.0224
Xiaoning Gan, Guanqi Dai, Yonghao Li, Lin Xu, Guolong Liu
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Abstract

Gender disparities are evident across different types of digestive system cancers, which are typically characterized by a lower incidence and mortality rate in females compared to males. This finding suggests a potential protective role of female steroid hormones, particularly estrogen, in the development of these cancers. Estrogen is a well-known sex hormone that not only regulates the reproductive system but also exerts diverse effects on non-reproductive organs mediated through interactions with estrogen receptors (ERs), including the classic (ERα and ERβ) and non-traditional ERs [G protein-coupled estrogen receptor (GPER)]. Recent advances have contributed to our comprehension of the mechanisms underlying ERs in digestive system cancers. In this comprehensive review we summarize the current understanding of the intricate roles played by estrogen and ERs in the major types of digestive system cancers, including hepatocellular, pancreatic, esophageal, gastric, and colorectal carcinoma. Furthermore, we discuss the potential molecular mechanisms underlying ERα, ERβ, and GPER effects, and propose perspectives on innovative therapies and preventive measures targeting the pathways regulated by estrogen and ERs. The roles of estrogen and ERs in digestive system cancers are complicated and depend on the cell type and tissue involved. Additionally, deciphering the intricate roles of estrogen, ERs, and the associated signaling pathways may guide the discovery of novel and tailored therapeutic and preventive strategies for digestive system cancers, eventually improving the care and clinical outcomes for the substantial number of individuals worldwide affected by these malignancies.

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雌激素和雌激素受体在消化系统癌症中的复杂作用:系统综述。
在不同类型的消化系统癌症中,性别差异是显而易见的,这些癌症的典型特征是女性的发病率和死亡率低于男性。这一发现表明,女性类固醇激素,尤其是雌激素,在这些癌症的发病过程中可能起着保护作用。雌激素是一种众所周知的性激素,它不仅能调节生殖系统,还能通过与雌激素受体(ER)(包括传统的ERα和ERβ)和非传统的ER[G蛋白偶联雌激素受体(GPER)]相互作用,对非生殖器官产生多种影响。最近的研究进展有助于我们理解ERs在消化系统癌症中的作用机制。在这篇综述中,我们总结了目前对雌激素和ERs在肝细胞癌、胰腺癌、食管癌、胃癌和结直肠癌等主要类型的消化系统癌症中所扮演的复杂角色的理解。此外,我们还讨论了ERα、ERβ和GPER效应的潜在分子机制,并对针对雌激素和ER调控途径的创新疗法和预防措施提出了展望。雌激素和ERs在消化系统癌症中的作用非常复杂,取决于所涉及的细胞类型和组织。此外,破译雌激素、雌激素受体和相关信号通路的复杂作用可能有助于发现新型的、有针对性的消化系统癌症治疗和预防策略,最终改善全球大量受这些恶性肿瘤影响的人的治疗和临床结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancer Biology & Medicine
Cancer Biology & Medicine Medicine-Oncology
CiteScore
9.80
自引率
3.60%
发文量
1143
审稿时长
12 weeks
期刊介绍: Cancer Biology & Medicine (ISSN 2095-3941) is a peer-reviewed open-access journal of Chinese Anti-cancer Association (CACA), which is the leading professional society of oncology in China. The journal quarterly provides innovative and significant information on biological basis of cancer, cancer microenvironment, translational cancer research, and all aspects of clinical cancer research. The journal also publishes significant perspectives on indigenous cancer types in China.
期刊最新文献
Potential treatment approaches for malignant peritoneal mesothelioma: in vivo and in vitro experimental study of natural killer cell immunotherapy. Inflammatory signaling in targeted therapy resistance: focus on EGFR-targeted treatment. Intricate roles of estrogen and estrogen receptors in digestive system cancers: a systematic review. Personalized laparoscopic radical resection of gallbladder cancer by staining of the liver draining area through ICG injection into the cholecystic artery. Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies.
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