JC Polyomavirus Nephropathy: A Rare Complication Late after Kidney Transplantation.

IF 0.7 Q4 UROLOGY & NEPHROLOGY Case Reports in Nephrology and Dialysis Pub Date : 2024-08-29 eCollection Date: 2024-01-01 DOI:10.1159/000540294
Jennifer Scotti Gerber, Sara De Marchi, Ariana Gaspert, Thomas Fehr, Pietro E Cippà
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Abstract

Introduction: JC-polyomavirus-associated nephropathy (JC-PVAN) is a rare cause of allograft dysfunction with only a few cases described in the literature.

Case presentation: We present 2 cases of JC-PVAN, both of which occurred >5 years after kidney transplantation. In both cases, transplant biopsies were performed because of worsening of kidney function. We found tubulitis and interstitial inflammation; immunohistochemistry was positive for SV40, but BK virus was not detected. The presence of JC virus confirmed the diagnosis of JC-PVAN. Immunosuppressive therapy was adopted, but in both cases graft function progressively deteriorated.

Conclusions: Our cases show that JC-PVAN, although much rarer than BK-PVAN, should be considered a possible cause of graft dysfunction even years after transplantation. Complete diagnostic workup, including kidney biopsy, is crucial for correct diagnosis and treatment.

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JC 多瘤病毒肾病:肾移植术后晚期的罕见并发症。
导言:JC-多瘤病毒相关肾病(JC-PVAN)是一种罕见的导致同种异体移植肾功能障碍的病因,文献中仅描述了几例:我们介绍了 2 例 JC-PVAN 病例,两例均发生在肾移植后 5 年以上。两例病例均因肾功能恶化而进行了移植活检。我们发现了肾小管炎和间质性炎症;免疫组化结果显示 SV40 阳性,但未检测到 BK 病毒。JC 病毒的存在证实了 JC-PVAN 的诊断。虽然采取了免疫抑制治疗,但两例患者的移植物功能均逐渐恶化:结论:我们的病例表明,JC-PVAN 虽然比 BK-PVAN 少见得多,但应被视为移植后数年仍可能导致移植物功能障碍的原因之一。完整的诊断工作,包括肾活检,对于正确诊断和治疗至关重要。
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来源期刊
CiteScore
1.20
自引率
0.00%
发文量
36
审稿时长
10 weeks
期刊介绍: This peer-reviewed online-only journal publishes original case reports covering the entire spectrum of nephrology and dialysis, including genetic susceptibility, clinical presentation, diagnosis, treatment or prevention, toxicities of therapy, critical care, supportive care, quality-of-life and survival issues. The journal will also accept case reports dealing with the use of novel technologies, both in the arena of diagnosis and treatment. Supplementary material is welcomed.
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