Application and new findings of scRNA-seq and ST-seq in prostate cancer.

IF 4 Q2 CELL & TISSUE ENGINEERING Cell Regeneration Pub Date : 2024-10-29 DOI:10.1186/s13619-024-00206-w
Zhuang Li, Zhengnan Li, Yuanyuan Luo, Weiming Chen, Yinyi Fang, Yuliang Xiong, Qinyi Zhang, Dongbo Yuan, Bo Yan, Jianguo Zhu
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Abstract

Prostate cancer is a malignant tumor of the male urological system with the highest incidence rate in the world, which seriously threatens the life and health of middle-aged and elderly men. The progression of prostate cancer involves the interaction between tumor cells and tumor microenvironment. Understanding the mechanisms of prostate cancer pathogenesis and disease progression is important to guide diagnosis and therapy. The emergence of single-cell RNA sequencing (scRNA-seq) and spatial transcriptome sequencing (ST-seq) technologies has brought breakthroughs in the study of prostate cancer. It makes up for the defects of traditional techniques such as fluorescence-activated cell sorting that are difficult to elucidate cell-specific gene expression. This review summarized the heterogeneity and functional changes of prostate cancer and tumor microenvironment revealed by scRNA-seq and ST-seq, aims to provide a reference for the optimal diagnosis and treatment of prostate cancer.

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scRNA-seq 和 ST-seq 在前列腺癌中的应用和新发现。
前列腺癌是世界上发病率最高的男性泌尿系统恶性肿瘤,严重威胁着中老年男性的生命健康。前列腺癌的进展涉及肿瘤细胞与肿瘤微环境之间的相互作用。了解前列腺癌的发病机制和疾病进展对指导诊断和治疗非常重要。单细胞 RNA 测序(scRNA-seq)和空间转录组测序(ST-seq)技术的出现为前列腺癌的研究带来了突破性进展。它弥补了荧光激活细胞分选等传统技术难以阐明细胞特异性基因表达的缺陷。本综述总结了scRNA-seq和ST-seq揭示的前列腺癌和肿瘤微环境的异质性和功能变化,旨在为前列腺癌的优化诊断和治疗提供参考。
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来源期刊
Cell Regeneration
Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
5.80
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine
期刊最新文献
Application and new findings of scRNA-seq and ST-seq in prostate cancer. Beyond resorption: osteoclasts as drivers of bone formation. Subtype-specific neurons from patient iPSCs display distinct neuropathological features of Alzheimer's disease. Targeting senescent cells in aging and COVID-19: from cellular mechanisms to therapeutic opportunities. Chromatin remodeling in tissue stem cell fate determination.
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