JAK 2-Positive Diseases and Spontaneous Coronary Artery Dissection: Case Series.

IF 0.7 Q4 ONCOLOGY Case Reports in Oncology Pub Date : 2024-09-12 eCollection Date: 2024-01-01 DOI:10.1159/000541036

Ahmed K A Yasin, Shehab Fareed Mohamed, Elmustafa Abdalla, Girish Rao, Abdulaziz M Alkhulaifi, Mohamed A Yassin, Deena Mudawi, Abdulrahman Fadhl Al-Mashdali, Samah Kohla, Feryal A Ibrahim, Dina Soliman, Cornelia S Carr

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Abstract

Introduction: Chronic myeloproliferative neoplasms (MPNs) such as polycythaemia vera (PV) and essential thrombocytosis are associated with atherosclerosis and cardiovascular events, especially if JAK2 mutation is there. In rare cases, also spontaneous coronary artery dissection (SCAD) can be seen.

Case presentation: This case series describes two case reports of MPNs in which SCAD was found in both of them in addition to standard atherosclerosis. First one was about a 42-year-old man who was admitted for acute myocardial infarction (MI) and was later found to have PV and SCAD. The second one was about a 52-year-old man who was also admitted for acute MI and was later found to have SCAD and essential thrombocythemia. JAK2V617F missense mutation was found in both cases.

Conclusion: MPNs with JAK2 mutations are associated with SCAD in addition to usual atherosclerosis. This association needs further research.

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JAK 2 阳性疾病与自发性冠状动脉夹层：病例系列。

导言：慢性骨髓增生性肿瘤（MPNs），如多发性红细胞增多症（PV）和原发性血小板增多症，与动脉粥样硬化和心血管事件有关，尤其是在JAK2基因突变的情况下。在极少数病例中，也可出现自发性冠状动脉夹层（SCAD）：本病例系列描述了两例 MPN 病例报告，在这两例病例中，除了标准的动脉粥样硬化外，还发现了自发性冠状动脉夹层（SCAD）。第一个病例是一名 42 岁的男性，因急性心肌梗死（MI）入院，后来被发现患有 PV 和 SCAD。第二例涉及一名 52 岁的男子，他也因急性心肌梗死入院，后来发现患有 SCAD 和原发性血小板增多症。两例病例均发现了JAK2V617F错义突变：结论：JAK2突变的多发性骨髓瘤除常见的动脉粥样硬化外，还与SCAD有关。这种关联需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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