A Study on the Rationality of Baicalein in the Treatment of Osteoporosis: A Narrative Review.

IF 1.9 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Current protein & peptide science Pub Date : 2024-10-25 DOI:10.2174/0113892037325783240912072039

Qi Li, Xingyan Ma, Xiaodong Xu, Chengming Zhang, Weiguo Wang

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Abstract

Baicalein (BN) is an active ingredient naturally present in Chinese herbs, such as Scutellaria baicalein, Coptis chinensis, and Dendrobium officinale. It has a variety of pharmacological activities, including antioxidant, anti-inflammatory and antibacterial effects. Therefore, Baicalein (BN) is widely used in the field of medicine and is considered a potential natural medicine. Osteoporosis (OP) is a bone metabolic disease characterized by decreased bone mineral density and bone structure destruction, which is mainly caused by decreased bone formation and increased bone resorption. With the continuous development of molecular biology, the signaling pathways and gene targets of bone metabolism are also expanding. Recent studies have shown that baicalein may affect the function of osteoblasts, osteoclasts, and bone marrow mesenchymal stem cells through MAPK/ERK and MAPKs/NF-κB signaling pathways, so as to have a therapeutic effect on OP. However, the specific mechanism of baicalein in the treatment of OP is still unclear. This article reviews the literature, analyzes and summarizes the mechanism of action of baicalein, and discusses its potential in the prevention and treatment of OP, so as to provide a basis for the clinical application of baicalein.

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关于黄芩苷治疗骨质疏松症合理性的研究：叙述性综述。

黄芩苷（BN）是一种天然存在于黄芩、黄连和铁皮石斛等中草药中的活性成分。它具有多种药理活性，包括抗氧化、抗炎和抗菌作用。因此，黄芩素（BN）被广泛应用于医学领域，并被视为一种潜在的天然药物。骨质疏松症（OP）是一种以骨矿物质密度降低和骨结构破坏为特征的骨代谢疾病，主要由骨形成减少和骨吸收增加引起。随着分子生物学的不断发展，骨代谢的信号通路和基因靶点也在不断扩展。最新研究表明，黄芩苷可通过MAPK/ERK和MAPKs/NF-κB信号通路影响成骨细胞、破骨细胞和骨髓间充质干细胞的功能，从而对OP产生治疗作用。然而，黄芩苷治疗 OP 的具体机制尚不清楚。本文通过文献综述，分析总结黄芩苷的作用机制，探讨其在预防和治疗 OP 方面的潜力，为黄芩苷的临床应用提供依据。

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来源期刊

Current protein & peptide science 生物-生化与分子生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.