Hybrid/Chimera Drugs - Part 1 - Drug Hybrids Affecting Diseases of the Central Nervous System.

IF 3.5 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current medicinal chemistry Pub Date : 2024-10-28 DOI:10.2174/0109298673305662240702071354
Abraham Nudelman
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Abstract

This review, focused on hybrid drugs, is the third in a series of reviews, where the first two reviews dealt with a) dimeric drugs, b) mutual prodrugs - codrugs. The compounds designated as hybrids are comprised of two (and sometimes three) biologically active entities, linked by metabolically stable bridges. In some cases, one of the two components of the hybrids serves as a carrier for the second component, and most frequently, the components elicit their individual biological properties, which are commonly synergistic or complementary. Due to the very large number of publications dealing with hybrid drugs, the present review is restricted to hybrids acting in the central nervous system. Future reviews will cover fields such as antimicrobial, anticancer, and antiviral hybrids, and cardiovascular active hybrids. The selected articles reviewed herein were published between the years 2000-2022 with partial coverage of the year 2023.

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杂交/奇美拉药物 - 第 1 部分 - 影响中枢神经系统疾病的杂交药物。
本综述以杂交药物为重点,是系列综述的第三篇,前两篇综述涉及 a) 二聚体药物,b) 互为原药--同源药。被称为杂合剂的化合物由两个(有时是三个)生物活性实体组成,并通过代谢稳定的桥连接在一起。在某些情况下,混合物的两种成分之一可作为第二种成分的载体,而最常见的情况是,这两种成分各自具有协同或互补的生物特性。由于涉及杂交药物的出版物非常多,本综述仅限于作用于中枢神经系统的杂交药物。今后的综述将涉及抗菌、抗癌和抗病毒混合药物以及心血管活性混合药物等领域。本综述所选文章发表于 2000-2022 年间,部分文章发表于 2023 年。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current medicinal chemistry
Current medicinal chemistry 医学-生化与分子生物学
CiteScore
8.60
自引率
2.40%
发文量
468
审稿时长
3 months
期刊介绍: Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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