Association between prenatal maternal sleep quality, neonatal uncinate fasciculus white matter, and infant negative emotionality.

IF 9.7 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL EBioMedicine Pub Date : 2024-11-01 Epub Date: 2024-10-30 DOI:10.1016/j.ebiom.2024.105384
Melissa Nevarez-Brewster, Catherine H Demers, LillyBelle K Deer, Özlü Aran, Robert J Gallop, Mercedes Hoeflich Haase, Khalid Al-Ali, Maria M Bagonis, John H Gilmore, M Camille Hoffman, Martin A Styner, Benjamin L Hankin, Elysia Poggi Davis
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Abstract

Background: Poor prenatal maternal sleep is a pervasive, yet modifiable, health concern affecting maternal and foetal wellbeing. Experimental rodent studies demonstrate that prenatal maternal sleep deprivation affects offspring brain development and leads to adverse outcomes, including increased anxiety-like behaviour. We examined the relation between prenatal maternal sleep quality and neonatal white matter development and subsequent infant negative emotionality.

Methods: Participants included 116 mother-infant (53% female) dyads. Prenatal sleep quality was prospectively assessed three times during gestation (16, 29, and 35 gestational weeks) using the Pittsburgh Sleep Quality Index. Neonatal white matter, as indexed by fractional anisotropy (FA), was assessed via diffusion weighted magnetic resonance imaging. Negative emotionality was measured via behavioural observation and maternal report when the infant was 6-months of age.

Findings: More prenatal sleep problems across pregnancy were associated with higher neonatal FA in the uncinate fasciculus (left: b = 0.20, p = .004; right: b = 0.15, p = .027). Higher neonatal uncinate FA was linked to infant negative emotionality, and uncinate FA partially mediated the association between prenatal maternal sleep and behavioural observation of infant negative emotionality.

Interpretation: Findings highlight prenatal sleep as an environmental signal that affects the developing neonatal brain and later infant negative emotionality.

Funding: National Institutes of Health (R01MH109662, R01HL155744, P50HD103573, K12AR084226, F32 Training fellowships MH125572, HL165844, MH106440, and diversity supplement R01HL155744-01S1).

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产前母体睡眠质量、新生儿钩状束白质与婴儿负面情绪之间的关系。
背景:产前母体睡眠不足是一个普遍存在但可改变的健康问题,会影响母体和胎儿的健康。啮齿动物实验研究表明,产前母亲睡眠不足会影响后代的大脑发育并导致不良后果,包括焦虑行为的增加。我们研究了产前母亲睡眠质量与新生儿白质发育及随后婴儿负面情绪之间的关系:研究对象包括116对母婴组合(53%为女性)。在妊娠期间(16、29 和 35 孕周),使用匹兹堡睡眠质量指数对产前睡眠质量进行了三次前瞻性评估。新生儿白质以分数各向异性(FA)为指标,通过扩散加权磁共振成像进行评估。在婴儿6个月大时,通过行为观察和母亲报告来测量负面情绪:结果:妊娠期产前睡眠问题较多与新生儿钩状束FA较高有关(左侧:b = 0.20,p = .004;右侧:b = 0.15,p = .027)。新生儿较高的钩状束FA与婴儿的消极情绪有关,钩状束FA部分介导了产前母亲睡眠与婴儿消极情绪行为观察之间的关联:研究结果表明,产前睡眠是影响新生儿大脑发育和日后婴儿负面情绪的环境信号:美国国立卫生研究院(R01MH109662、R01HL155744、P50HD103573、K12AR084226、F32培训奖学金MH125572、HL165844、MH106440和多样性补充R01HL155744-01S1)。
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来源期刊
EBioMedicine
EBioMedicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
17.70
自引率
0.90%
发文量
579
审稿时长
5 weeks
期刊介绍: eBioMedicine is a comprehensive biomedical research journal that covers a wide range of studies that are relevant to human health. Our focus is on original research that explores the fundamental factors influencing human health and disease, including the discovery of new therapeutic targets and treatments, the identification of biomarkers and diagnostic tools, and the investigation and modification of disease pathways and mechanisms. We welcome studies from any biomedical discipline that contribute to our understanding of disease and aim to improve human health.
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