The regulation of pyroptosis by post-translational modifications: molecular mechanisms and therapeutic targets.

IF 9.7 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL EBioMedicine Pub Date : 2024-10-29 DOI:10.1016/j.ebiom.2024.105420

Yi-Rao Zhou, Jun-Jie Dang, Qi-Chao Yang, Zhi-Jun Sun

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Abstract

Pyroptosis, a type of programmed cell death mediated by gasdermin family proteins, releases a large amount of immune stimulatory substances, which further contribute to inflammation and elicit an adaptive immune response against tumours and pathogens. And it occurs through multiple pathways that involve the activation of specific caspases and the cleavage of gasdermins. Post-translational modifications (PTMs) could influence the chemical properties of the modified residues and neighbouring regions, ultimately affecting the activity, stability, and functions of proteins to regulate pyroptosis. Many studies have been conducted to explore the influence of PTMs on the regulation of pyroptosis. In this review, we provide a comprehensive summary of different types of PTMs that influence pyroptosis, along with their corresponding modifying enzymes. Moreover, it elaborates on the specific contributions of different PTMs to pyroptosis and delves into how the regulation of these modifications can be leveraged for therapeutic interventions in cancer and inflammatory diseases.

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翻译后修饰对热蛋白沉积的调控：分子机制和治疗靶点。

细胞凋亡是一种由气体蛋白家族蛋白介导的程序性细胞死亡，它释放出大量的免疫刺激物质，进一步促进炎症，并引发针对肿瘤和病原体的适应性免疫反应。它通过多种途径发生，包括激活特定的 Caspases 和裂解 gasdermins。翻译后修饰（PTM）可影响修饰残基和邻近区域的化学性质，最终影响蛋白质的活性、稳定性和功能，从而调控热蛋白沉积。许多研究都在探索 PTM 对热核糖变调控的影响。在这篇综述中，我们全面总结了影响化脓过程的不同类型的 PTMs 及其相应的修饰酶。此外，它还阐述了不同 PTM 对热蛋白沉积的具体贡献，并深入探讨了如何利用这些修饰的调控对癌症和炎症性疾病进行治疗干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EBioMedicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

17.70

自引率

0.90%

发文量

579

审稿时长

5 weeks

期刊介绍： eBioMedicine is a comprehensive biomedical research journal that covers a wide range of studies that are relevant to human health. Our focus is on original research that explores the fundamental factors influencing human health and disease, including the discovery of new therapeutic targets and treatments, the identification of biomarkers and diagnostic tools, and the investigation and modification of disease pathways and mechanisms. We welcome studies from any biomedical discipline that contribute to our understanding of disease and aim to improve human health.