Repetitive transcranial magnetic stimulation in murine models of epilepsy: A systematic review of methodological aspects and outcomes

IF 2 4区医学 Q3 CLINICAL NEUROLOGY Epilepsy Research Pub Date : 2024-10-24 DOI:10.1016/j.eplepsyres.2024.107468

Vasilis-Spyridon Tseriotis , Vasilios K. Kimiskidis , David-Dimitris Chlorogiannis , Marianthi Arnaoutoglou , Dimitrios Kouvelas , Georgios Konstantis , Sofia Karachrysafi , Faye Malliou , Paraskevas Mavropoulos , Marina Manani , Stavroula Koukou , Chryssa Pourzitaki

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Abstract

Objectives

Clinical studies of repetitive transcranial magnetic stimulation (rTMS) do not provide consistent efficacy results, possibly due to variability in methodological parameters. Our aim is to systematically review preclinical rTMS protocols in murine models of epilepsy, offering insights from might facilitate the optimization of clinical trials.

Methods

We searched MEDLINE, SCOPUS and Web of Science from inception until December 2023, including English-written and peer-reviewed studies with clinical or electroencephalographic (EEG) outcomes.

Results

Among 480 search results, in the 23 eligible studies both mice and rats were used. Epilepsy induction methods included injections of pentylenetetrazole, kainic acid, picrotoxin and lithium-pilocarpine, electrical kindling (amygdala/ventral hippocampus), electroconvulsive shock and genetic models of absence and temporal lobe epilepsy. For motor threshold (MT) definition electromyography with motor evoked potentials and single-pulse TMS were used. Stimulation intensity ranged between 40 % and 200 % of MT or 0.125–2.5 T. High-frequency rTMS (≥5 Hz) demonstrated either no effect on seizure suppression or a rather facilitatory effect, promoting ictogenesis, with the exception of 20-Hz-rTMS coupling with lorazepam for status epilepticus cessation. Low-frequency rTMS (<5 Hz), primarily at 0.5 and 1 Hz, exerted an inhibitory effect on both clinical and EEG parameters on various epilepsy models in most studies and also significantly ameliorated performance in behavioral tests.

Conclusions

rTMS holds potential for effective neuromodulation, that is critically dependent on stimulation frequency and epilepsy type. Translational knowledge gained from preclinical protocols may inform and optimize rTMS application for epilepsy management in future clinical trials.

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小鼠癫痫模型中的重复经颅磁刺激：方法和结果的系统回顾。

目的：重复经颅磁刺激（rTMS）的临床研究并没有提供一致的疗效结果，这可能是由于方法参数的差异造成的。我们的目的是系统回顾小鼠癫痫模型的临床前经颅磁刺激方案，为临床试验的优化提供启示：我们检索了从开始到 2023 年 12 月的 MEDLINE、SCOPUS 和 Web of Science，包括有临床或脑电图（EEG）结果的英文撰写和同行评审研究：在 480 项搜索结果中，有 23 项符合条件的研究同时使用了小鼠和大鼠。癫痫诱导方法包括注射戊四唑、凯因酸、微毒毒素和锂-匹罗卡品、电点燃（杏仁核/海马内侧）、电休克以及失神和颞叶癫痫遗传模型。在确定运动阈值（MT）时，使用了肌电图和运动诱发电位以及单脉冲 TMS。刺激强度介于 MT 的 40% 和 200% 之间，或 0.125-2.5 T。高频经颅磁刺激（≥5 Hz）对癫痫发作的抑制没有效果，或有促进作用，可促进癫痫发生，但 20 Hz 经颅磁刺激与劳拉西泮联用可终止癫痫状态。低频经颅磁刺激（结论：经颅磁刺激具有有效神经调节的潜力，但关键取决于刺激频率和癫痫类型。从临床前方案中获得的转化知识可在未来的临床试验中为经颅磁刺激治疗癫痫的应用提供信息并进行优化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsy Research 医学-临床神经学

CiteScore

0.10

自引率

4.50%

发文量

143

审稿时长

62 days

期刊介绍： Epilepsy Research provides for publication of high quality articles in both basic and clinical epilepsy research, with a special emphasis on translational research that ultimately relates to epilepsy as a human condition. The journal is intended to provide a forum for reporting the best and most rigorous epilepsy research from all disciplines ranging from biophysics and molecular biology to epidemiological and psychosocial research. As such the journal will publish original papers relevant to epilepsy from any scientific discipline and also studies of a multidisciplinary nature. Clinical and experimental research papers adopting fresh conceptual approaches to the study of epilepsy and its treatment are encouraged. The overriding criteria for publication are novelty, significant clinical or experimental relevance, and interest to a multidisciplinary audience in the broad arena of epilepsy. Review articles focused on any topic of epilepsy research will also be considered, but only if they present an exceptionally clear synthesis of current knowledge and future directions of a research area, based on a critical assessment of the available data or on hypotheses that are likely to stimulate more critical thinking and further advances in an area of epilepsy research.