RETRACTION: Neuroprotective Activities of Activated Protein C Mutant With Reduced Anticoagulant Activity

Abstract

RETRACTION: H. Guo, I. Singh, Y. Wang, R. Deane, T. Barrett, J. A. Fernández, N. Chow, J. H. Griffin and B. V. Zlokovic, “Neuroprotective Activities of Activated Protein C Mutant With Reduced Anticoagulant Activity,” European Journal of Neuroscience 29, no. 6 (2009): 1119–1130, https://doi.org/10.1111/j.1460-9568.2009.06664.x.

The above article, published online on 16 March 2009 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editors-in-Chief, John Foxe and Yoland Smith; the Federation of European Neuroscience Societies; and John Wiley & Sons Ltd. The retraction has been agreed as the corresponding author contacted the editors of European Journal of Neuroscience reporting that similarities were observed between Figure 1a of this article and another figure published elsewhere. The latter figure was published five years earlier by some of the same authors and represents a different experiment.

Following an investigation, it was found that the duplicated images showed signs of cropping and digital manipulation. The authors provided some raw data but were unable to provide the original micrographs for figure 1a; instead, they shared results from recently repeated experiments. However, questions remain regarding the rigor devoted to the collection and analysis of data presented in this article; as a result, the journal retracts this article. The authors disagree with the retraction.