The role of ferroptosis in neurodegenerative diseases.

IF 4.2 3区 医学 Q2 NEUROSCIENCES Frontiers in Cellular Neuroscience Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI:10.3389/fncel.2024.1475934
Yifan Fei, Yifei Ding
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Abstract

Ferroptosis represents an iron- and lipid peroxidation (LPO)-mediated form of regulated cell death (RCD). Recent evidence strongly suggests the involvement of ferroptosis in various neurodegenerative diseases (NDs), particularly Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), among others. The treatment of ferroptosis poses both opportunities and challenges in the context of ND. This review provides a comprehensive overview of characteristic features, induction and inhibition of ferroptosis, highlighting the ferroptosis inhibitor and the underlying mechanisms responsible for its occurrence. Moreover, the review explores how these mechanisms contribute to the pathogenesis and progression of major neurodegenerative disorders. Additionally, it presents novel insights into the role of ferroptosis in ND and summarizes recent advancements in the development of therapeutic approaches targeting ferroptosis. These insights and advancements hold potential to guide future strategies aimed at effectively managing these debilitating medical conditions.

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铁蛋白沉积症在神经退行性疾病中的作用
铁变性是铁和脂质过氧化(LPO)介导的一种调节性细胞死亡(RCD)形式。最近的证据有力地表明,铁变性参与了各种神经退行性疾病(NDs),尤其是阿尔茨海默病(AD)、帕金森病(PD)、亨廷顿病(HD)、多发性硬化症(MS)和肌萎缩侧索硬化症(ALS)等。在 ND 的背景下,铁中毒的治疗既是机遇也是挑战。本综述全面概述了铁变态反应的特征、诱导和抑制,强调了铁变态反应抑制剂及其发生的内在机制。此外,该综述还探讨了这些机制如何促进主要神经退行性疾病的发病和进展。此外,它还介绍了有关铁蛋白沉积在 ND 中的作用的新见解,并总结了在开发针对铁蛋白沉积的治疗方法方面的最新进展。这些见解和进展有望指导未来的策略,从而有效控制这些使人衰弱的病症。
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来源期刊
CiteScore
7.90
自引率
3.80%
发文量
627
审稿时长
6-12 weeks
期刊介绍: Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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