Advances in understanding the regulation of pluripotency fate transition in embryonic stem cells.

IF 4.6 2区 生物学 Q2 CELL BIOLOGY Frontiers in Cell and Developmental Biology Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI:10.3389/fcell.2024.1494398
Yong Kang Jia, Yang Yu, Li Guan
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Abstract

Embryonic stem cells (ESCs) sourced from the inner cell mass of blastocysts, are akin to this tissue in function but lack the capacity to form all extraembryonic structures. mESCs are transient cell populations that express high levels of transcripts characteristic of 2-cell (2C) embryos and are identified as "2-cell-like cells" (2CLCs). Previous studies have shown that 2CLCs can contribute to both embryonic and extraembryonic tissues upon reintroduction into early embryos. Approximately 1% of mESCs dynamically transition from pluripotent mESCs into 2CLCs. Nevertheless, the scarcity of mammalian embryos presents a significant challenge to the molecular characterization of totipotent cells. To date, Previous studies have explored various methods for reprogramming pluripotent cells into totipotent cells. While there is a good understanding of the molecular regulatory network maintaining ES pluripotency, the process by which pluripotent ESCs reprogram into totipotent cells and the associated molecular mechanisms of totipotent regulation remain poorly understood. This review synthesizes recent insights into the regulatory pathways of ESC reprogramming into 2CLC, exploring molecular mechanisms modulated by transcriptional regulators, small molecules, and epigenetic changes. The objective is to construct a theoretical framework for the field of researchers.

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了解胚胎干细胞多能性命运转变调控的进展。
胚胎干细胞(ESC)来源于胚泡的内细胞团,在功能上与胚泡组织相似,但缺乏形成所有胚外结构的能力。先前的研究表明,2CLCs 在重新导入早期胚胎后,可对胚胎组织和胚外组织做出贡献。约有 1% 的 mESCs 可从多能 mESCs 动态转变为 2CLCs 。然而,哺乳动物胚胎的稀缺性给全能细胞的分子鉴定带来了巨大挑战。迄今为止,以往的研究探索了将多能细胞重编程为全能细胞的各种方法。虽然人们对维持 ES 多能性的分子调控网络有了很好的了解,但对多能性 ESC 重编程为全能细胞的过程以及全能性调控的相关分子机制仍然知之甚少。这篇综述综述了ESC重编程为2CLC的调控途径的最新见解,探讨了由转录调控因子、小分子和表观遗传变化调控的分子机制。目的是为该领域的研究人员构建一个理论框架。
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来源期刊
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
9.70
自引率
3.60%
发文量
2531
审稿时长
12 weeks
期刊介绍: Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.
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