Phenotypic characterization and quality of life of Labradoodles with idiopathic epilepsy and epilepsy of unknown cause.

IF 2.6 2区农林科学 Q1 VETERINARY SCIENCES Frontiers in Veterinary Science Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI:10.3389/fvets.2024.1459260

Paul J J Mandigers, Simone E Meijs, Marta Plonek, Koen M Santifort, M Montserrat Diaz Espineira

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Abstract

Introduction: Idiopathic epilepsy (IE) is a common chronic neurological disorder in dogs. Breed specific knowledge on semiology, age of onset (AoO), seizure frequency, response to treatment, and Quality of Life (QoL) scores for both dog and owner are important. The Labradoodle is originally a cross between the Labrador Retriever and Standard Poodle. The aim of this study was to describe in detail the epilepsy, that is recognized in this designer breed.

Method: An online survey was distributed through several platforms to owners of Labradoodles. Only Labradoodles, either registered as such or bred as a Labradoodle were included. To classify the Labradoodles in a TIER level of confidence the criteria of the International Veterinary Task Force were used.

Results: Forty labradoodles were included. Thirty-three Labradoodles were classified as IE or suspected IE cases and appeared to have an AoO of 2.3 ± 1.3 years, and a seizure frequency of 5.4 ± 6.5 seizures/year (range 0-25). Seven dogs were classified as EUC, two dogs started before 6 months of age, and five dogs had their first seizures at 8.4 ± 1.2 years of age. The seizure frequency for all EUC dogs was 5.0 ± 3.0 seizures/year (range 0-11). Stress, for both the (suspected) IE and EUC cases, was the most frequently reported seizure precipitating factor (95% of the dogs). AoO and seizure frequency did not seem to be influenced by type of housing, type of owner, or the dog's character as interpreted by the owner. Cluster seizures (CS) were seen in 33% and status epilepticus (SE) in 10% of the included Labradoodles. Many dogs did not need treatment (38%) or only one anti-seizure medication (43%), in which case they tended to respond favorably to treatment. QoL scores were high for both dog (8.3 ± 1.8) and owner (7.3 ± 2.2).

Discussion: Compared to the progenitor breeds, epilepsy of Labradoodles is phenotypically like that of the Standard Poodle, except for the existence CS and SE in the Labradoodle. The epilepsy seen in this designer breed has a favorable outcome compared to several other breeds.

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患有特发性癫痫和不明原因癫痫的拉布拉多犬的表型特征和生活质量。

简介：特发性癫痫（IE）是犬常见的慢性神经系统疾病。有关犬种的特定知识，包括半身像、发病年龄 (AoO)、癫痫发作频率、对治疗的反应以及犬和主人的生活质量 (QoL) 评分，都非常重要。拉布拉多犬最初是拉布拉多寻回犬和标准贵宾犬的杂交品种。本研究的目的是详细描述这一设计犬种中可识别的癫痫：方法：我们通过多个平台向拉布拉多犬的主人发放了一份在线调查问卷。只有注册为拉布拉多犬或作为拉布拉多犬饲养的拉布拉多犬才包括在内。结果：40 只拉布拉多犬被纳入调查范围：结果：共纳入 40 只拉布拉多犬。33只拉布拉多犬被归类为IE或疑似IE病例，它们的活动期似乎为2.3±1.3年，发作频率为5.4±6.5次/年（范围0-25）。七只狗被归类为EUC，两只狗在6个月大前开始发病，五只狗在8.4 ± 1.2岁时首次发作。所有 EUC 狗的癫痫发作频率为 5.0 ± 3.0 次/年（范围 0-11）。在（疑似）IE和EUC病例中，压力是最常报告的癫痫发作诱因（95%的犬）。动物嗜睡和癫痫发作频率似乎不受住房类型、狗主人类型或狗主人所理解的狗的性格的影响。33% 的拉布拉多犬出现了群集性癫痫发作 (CS)，10% 的拉布拉多犬出现了癫痫状态 (SE)。许多狗不需要治疗（38%）或只需要一种抗癫痫药物（43%），在这种情况下，它们往往对治疗反应良好。狗狗（8.3 ± 1.8）和主人（7.3 ± 2.2）的 QoL 分数都很高：讨论：与原种犬相比，拉布拉多犬的癫痫在表型上与标准贵宾犬相似，只是在拉布拉多犬中存在 CS 和 SE。与其他几个品种相比，拉布拉多犬这一设计犬种的癫痫治疗效果较好。

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来源期刊

Frontiers in Veterinary Science Veterinary-General Veterinary

CiteScore

4.80

自引率

9.40%

发文量

1870

审稿时长

14 weeks

期刊介绍： Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy. Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field. Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.