Intestinal microflora and metabolites affect the progression of acute pancreatitis (AP).

IF 4.3 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gut Pathogens Pub Date : 2024-10-30 DOI:10.1186/s13099-024-00652-6
Zhenjiang Wang, Mingyi Guo, Sen Yang, Yuping Chen, Jianbin Cheng, Zaiwei Huang, Tongxu Wang, Xiaobei Luo, Xingxiang He, Dali Wang, Xiaohong Xu
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Abstract

Specific intestinal metabolites are closely associated with the classification, severity, and necrosis of acute pancreatitis (AP) and provide novel insights for in-depth clinical investigations. In this study, the gut microbiota and metabolites of 49 AP patients at different treatment stages and severities were analysed via 16S rDNA sequencing and untargeted metabolomics to investigate the trends in gut microbiota composition and metabolome profiles observed in patients with severe AP. These findings revealed an imbalance in intestinal flora homeostasis among AP patients characterized by a decrease in probiotics and an increase in opportunistic pathogens, which leads to damage to the intestinal mucosal barrier through reduced short-chain fatty acid (SCFA) secretion and disruption of the intestinal epithelium. This dysbiosis influences energy metabolism, anti-inflammatory responses, and immune regulation, and these results highlight significant differences in energy metabolism pathways. These findings suggest that the differential composition of intestinal flora, along with alterations in intestinal metabolites and metabolic pathways, contribute to the compromised integrity of the intestinal mucosal barrier and disturbances in energy metabolism in patients with severe AP.

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肠道微生物菌群和代谢物会影响急性胰腺炎(AP)的病情发展。
特定的肠道代谢物与急性胰腺炎(AP)的分类、严重程度和坏死密切相关,为深入临床研究提供了新的见解。本研究通过 16S rDNA 测序和非靶向代谢组学分析了 49 例处于不同治疗阶段和严重程度的急性胰腺炎患者的肠道微生物群和代谢物,以研究在重症急性胰腺炎患者中观察到的肠道微生物群组成和代谢组特征的变化趋势。这些研究结果表明,AP 患者的肠道菌群平衡失调,其特点是益生菌减少,机会性病原体增加,导致短链脂肪酸(SCFA)分泌减少和肠道上皮细胞破坏,从而破坏肠道粘膜屏障。这种菌群失调会影响能量代谢、抗炎反应和免疫调节,这些结果突显了能量代谢途径的显著差异。这些研究结果表明,肠道菌群组成的差异以及肠道代谢产物和代谢途径的改变,导致严重 AP 患者肠道粘膜屏障的完整性受损和能量代谢紊乱。
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来源期刊
Gut Pathogens
Gut Pathogens GASTROENTEROLOGY & HEPATOLOGY-MICROBIOLOGY
CiteScore
7.70
自引率
2.40%
发文量
43
期刊介绍: Gut Pathogens is a fast publishing, inclusive and prominent international journal which recognizes the need for a publishing platform uniquely tailored to reflect the full breadth of research in the biology and medicine of pathogens, commensals and functional microbiota of the gut. The journal publishes basic, clinical and cutting-edge research on all aspects of the above mentioned organisms including probiotic bacteria and yeasts and their products. The scope also covers the related ecology, molecular genetics, physiology and epidemiology of these microbes. The journal actively invites timely reports on the novel aspects of genomics, metagenomics, microbiota profiling and systems biology. Gut Pathogens will also consider, at the discretion of the editors, descriptive studies identifying a new genome sequence of a gut microbe or a series of related microbes (such as those obtained from new hosts, niches, settings, outbreaks and epidemics) and those obtained from single or multiple hosts at one or different time points (chronological evolution).
期刊最新文献
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