LHPre: Phage Host Prediction with VAE-based Class Imbalance Correction and Lyase Sequence Embedding.

IF 3.6 3区 生物学 Q2 BIOCHEMICAL RESEARCH METHODS IEEE/ACM Transactions on Computational Biology and Bioinformatics Pub Date : 2024-10-30 DOI:10.1109/TCBB.2024.3488059
Jia Wang, Zhenjing Yu, Jianqiang Li
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Abstract

The escalation of antibiotic resistance underscores the need for innovative approaches to combat bacterial infections. Phage therapy has emerged as a promising solution, wherein host determination plays an important role. Phage lysins, characterized by their specificity in targeting and cleaving corresponding host bacteria, serve as key players in this paradigm. In this study, we present a novel approach by leveraging genes of phage-encoded lytic enzymes for host prediction, culminating in the development of LHPre. Initially, gene fragments of phage-encoded lytic enzymes and their respective hosts were collected from the database. Secondly, DNA sequences were encoded using the Frequency Chaos Game Representation (FCGR) method, and pseudo samples were generated employing the Variational Autoencoder (VAE) model to address class imbalance. Finally, a prediction model was constructed using the Vision Transformer(Vit) model. Five-fold cross-validation results demonstrated that LHPre surpassed other state-of-the-art phage host prediction methods, achieving accuracies of 85.04%, 90.01%, and 93.39% at the species, genus, and family levels, respectively.

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LHPre:利用基于 VAE 的类不平衡校正和 Lyase 序列嵌入进行噬菌体宿主预测。
抗生素耐药性的升级凸显了采用创新方法抗击细菌感染的必要性。噬菌体疗法已成为一种前景广阔的解决方案,其中宿主决定起着重要作用。噬菌体溶菌素具有靶向和裂解相应宿主细菌的特异性,是这一模式中的关键角色。在这项研究中,我们提出了一种新方法,利用噬菌体编码的溶菌酶基因进行宿主预测,最终开发出 LHPre。首先,我们从数据库中收集了噬菌体编码的溶菌酶基因片段及其各自的宿主。其次,利用频率混沌博弈表示法(FCGR)对DNA序列进行编码,并利用变异自动编码器(VAE)模型生成伪样本,以解决类不平衡问题。最后,利用视觉转换器(Vit)模型构建了一个预测模型。五倍交叉验证结果表明,LHPre 超越了其他最先进的噬菌体宿主预测方法,在种、属和科层面的准确率分别达到了 85.04%、90.01% 和 93.39%。
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来源期刊
CiteScore
7.50
自引率
6.70%
发文量
479
审稿时长
3 months
期刊介绍: IEEE/ACM Transactions on Computational Biology and Bioinformatics emphasizes the algorithmic, mathematical, statistical and computational methods that are central in bioinformatics and computational biology; the development and testing of effective computer programs in bioinformatics; the development of biological databases; and important biological results that are obtained from the use of these methods, programs and databases; the emerging field of Systems Biology, where many forms of data are used to create a computer-based model of a complex biological system
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